Blood Brain Barrier: Drug Delivery And Brain Pathology
Language: English
Published by Plenum Pub Corp, 2002
- Hardcover
- New
Seller: Basi6 International, Irving, TX, U.S.A.Basi6 International
AbeBooks seller since June 24, 2016
Condition: New
US$ 101.79
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- Title
- Blood Brain Barrier: Drug Delivery And Brain Pathology
- Author
- 0
- Publisher
- Plenum Pub Corp
- Publication year
- 2002
- Condition
- Brand New
- Binding
- Hardcover
- Language
- English
- ISBN 10
- 0306467089
- ISBN 13
- 9780306467080
The BBB, formed by a complex cellular system of endothelial cells, astroglia, pericytes, perivascular macrophages and a basal membrane, serves as a controlled functional gate to CNS. In vitro and in vivo models have been established to study the cellular and molecular interaction within the BBB and between the BBB and the neural cells.
The structural and functional integrity of the BBB was shown to be dramatically altered during various diseases of the CNS, including neoplasia, ischemia, trauma, inflammation and bacterial and viral infections.
Two approaches to drug delivery across the BBB have been pursued, based on either modulation of the permeability of the barrier or by conjugation of the drug to substrates of the active transport systems of the BBB.
"Synopsis" may belong to another edition of this title.
Basi6 International
Irving, TX, U.S.A.
AbeBooks seller since June 24, 2016
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