The Blood Brain Barrier and Inflammation

Ruth Lyck

ISBN 10: 3319455125 / ISBN 13: 9783319455129

Published by Springer, Springer Apr 2017, 2017

About this Item

This item is printed on demand - Print on Demand Titel. Neuware -This PIR volume presents a comprehensive collection of reviews that focus on the role of the blood-brain barrier (BBB) during steady-state and inflamed conditions. Within the central nervous system (CNS) the constantly changing bloodstream is strictly separated from the CNS parenchyma by the BBB. However, viruses, bacteria, parasites and auto-aggressive immune cells can penetrate the barrier and significantly contribute to CNS inflammation. The BBB can actively contribute to neuroinflammation by presentation of chemokines, expression of cell adhesion molecules and alterations of barrier properties. As such, understanding the role of the BBB under healthy and pathological conditions is essential to the development of new drugs to efficiently combat inflammatory diseases of the CNS.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 292 pp. Englisch.

Seller Inventory # 9783319455129

Bibliographic Details

• Title: The Blood Brain Barrier and Inflammation
• Publisher: Springer, Springer Apr 2017
• Publication Date: 2017
• Language: English
• ISBN 10: 3319455125
• ISBN 13: 9783319455129
• Binding: Buch
• Condition: Neu
• Dimensions: 241W x 160H x 21D millimeters 241 millimeters width by 160 millimeters height by 21 millimeters depth
• Weight: 659 grams

About this title

Synopsis

This PIR volume presents a comprehensive collection of reviews that focus on the role of the blood-brain barrier (BBB) during steady-state and inflamed conditions. Within the central nervous system (CNS) the constantly changing bloodstream is strictly separated from the CNS parenchyma by the BBB. However, viruses, bacteria, parasites and auto-aggressive immune cells can penetrate the barrier and significantly contribute to CNS inflammation. The BBB can actively contribute to neuroinflammation by presentation of chemokines, expression of cell adhesion molecules and alterations of barrier properties. As such, understanding the role of the BBB under healthy and pathological conditions is essential to the development of new drugs to efficiently combat inflammatory diseases of the CNS.

About the Author

Ruth Lyck (PD, PhD), group leader, Theodor-Kocher-Institute, Bern, Switzerland, works on extravasation of immune cells or metastasing cancer cells across the blood brain barrier. Gaby Enzmann (PhD), Research Associate, Theodor-Kocher-Institute, Bern, Switzerland, works on immune cell trafficking across the brain barriers into the central nervous system.