Brain : Fetal and Infant

Samuel R Berenberg

ISBN 10: 9401182213 / ISBN 13: 9789401182218

Published by Springer Jan 1977, 1977

About this Item

Neuware - In order to supplement Dr. Johnson's review we wish to make two points: I) not all grossly similar lesions should be considered t. o be due to the same etiology, even if experimentally documented, and 2) relatively few infections (syphilis, toxoplasmosis, cytomegalovirus, herpesvirus and rubella) and no immunologic disorders (except for kernicterus due to hyperbilirubinemia) are known to affect the developing human nervous system. Admittedly, since most human malformations are of unproven cause, these two points are not mutually exclusive. Rather, the challenge remains to show that any of the experimental models relates to any of the human diseases. In particular, the porencephaly-hydranencephaly spectrum could be due to ischemia in the watershed distribution of one or more branches of the internal carotid ar teries; and aqueductal stenosis could be due to secondary blockage by blood clots or debris related to hemorrhage or necrosis in the germinal matrix or periventricular white matter, lesions most likely due to hypoxia-acidosis in premature infant, who die most often of the concomitant respiratory distress syndrome. REFERENCES Altshuler. G. : Toxoplasmosis as a cause of hydranencephaly. Am. l. Dis. Child. 125: 251-252 (1973). Beer. A. E. and Billingham. R. E. : Immunobiology of mammalian reproduction. Adv. Immunol. 14: 1-84 (1971). Berenberg. W. and Nakervis. G. : Long-term follow-up of cytomegalic inclusion disease of in fancy. Pediatrics 46: 403-410 (1970). Boniuk. M. and Zimmerman. L. E. : Ocular pathology in the rubella syndrome. Arch. Ophthalmo! 77: 455-473 (1967).

Seller Inventory # 9789401182218

Bibliographic Details

• Title: Brain : Fetal and Infant
• Publisher: Springer Jan 1977
• Publication Date: 1977
• Language: English
• ISBN 10: 9401182213
• ISBN 13: 9789401182218
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 229W x 152H x 20D millimeters 229 millimeters width by 152 millimeters height by 20 millimeters depth
• Weight: 533 grams

About this title

Synopsis

In order to supplement Dr. Johnson's review we wish to make two points: I) not all grossly similar lesions should be considered t. o be due to the same etiology, even if experimentally documented, and 2) relatively few infections (syphilis, toxoplasmosis, cytomegalovirus, herpesvirus and rubella) and no immunologic disorders (except for kernicterus due to hyperbilirubinemia) are known to affect the developing human nervous system. Admittedly, since most human malformations are of unproven cause, these two points are not mutually exclusive. Rather, the challenge remains to show that any of the experimental models relates to any of the human diseases. In particular, the porencephaly-hydranencephaly spectrum could be due to ischemia in the watershed distribution of one or more branches of the internal carotid ar- teries; and aqueductal stenosis could be due to secondary blockage by blood clots or debris related to hemorrhage or necrosis in the germinal matrix or periventricular white matter, lesions most likely due to hypoxia-acidosis in premature infant, who die most often of the concomitant respiratory distress syndrome. REFERENCES Altshuler. G.: Toxoplasmosis as a cause of hydranencephaly. Am. l. Dis. Child. 125: 251-252 (1973). Beer. A. E. and Billingham. R. E.: Immunobiology of mammalian reproduction. Adv. Immunol. 14: 1-84 (1971). Berenberg. W. and Nakervis. G.: Long-term follow-up of cytomegalic inclusion disease of in- fancy. Pediatrics 46: 403-410 (1970). Boniuk. M. and Zimmerman. L. E.: Ocular pathology in the rubella syndrome. Arch. Ophthalmo!. 77: 455-473 (1967).