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2012 first edition, association copy (1977 Nobel winner Roger Guillemin), Springer (New York), 6 3/8 x 9 3/8 inches tall glossy blue hardcover, no dust jacket (as issued), white lettering to front cover and spine, copiously illustrated with black-and-white and color photographs and charts, index, xv, 198 pp. Laid in is a card reading, 'From the Private Collection of Dr. Roger and Lucienne Guillemin, Nobel Laureate, 1977, Salk Institute, La Jolla, CA.' Roger Charles Louis Guillemin was a French-American neuroscientist who received the National Medal of Science in 1976, and the Nobel Prize for Medicine in 1977 for his work on neurohormones. On the blank front free-endpaper, Guillemin wrote on a post-it note, 'Received from Karina G. July 5, 2013' referring to the daughter of author Armen Galoyan, Karina Galoyan, who mailed Guillemin the book after her father's death. Guillemin was a colleague and personal friend, something Guillemin describes in Armen Galoyan, In Memoriam, Neurochem Res 37, 2868?2869 (2012). The book is otherwise in near fine condition - clean, bright and unmarked. ~SP42~ [2.0P] Proline-rich polypeptides - in particular (PRP-1) galarmin and its structural analogues ? are, when isolated from the neurosecretory granules of neurohypophysis of humans and animals, a new type of hypothalamic peptides. They work against aerobic, anaerobic, gram-positive, and gram-negative microorganisms in vivo, and do not have etiotropic properties. They are unique and capable substitutes to antibiotics, and, moreover, may be effective against strains, such as MRSA, that develop resistance to antibiotics. Galarmin, a component of the brain neuroendocrine system produced by the neurosecretory cells of hypothalamus, possesses immunomodulatory, neuroprotective, antioxidant, antitumorigenic and hematopoietic properties. Moreover, galarmin and its structural analogues are powerful anti-inflammatory compounds. In addition to presenting a full overview of the neuroimmune system, it emphasizes the antibacterial, neuroprotective, and neuroregenerative properties of proline-rich polypeptides. It investigates the mechanism of galarmin?s action during different infectious processes, where it targets such dangerous pathogens as Bacillus anthracis, Clostridium perfringens, Mycobacterium tuberculosis, and Methicillin resistant Staphylococcus aureus. This research is important from both a theoretical and a clinical point of view, creating new prospects for the modern pharmaceutical industry and neuroendocrine, neuroimmunological sciences. Dr. Galoyan was a pioneer of the specialized field of neuroimmunology. During his 45-year long career, he discovered a neuroendocrine immune system of the brain and identified a new type of brain cytokines: proline-rich polypeptides. The most important of these, PRP-1 (galarmin) has been shown to possess antibacterial properties and protect from certain neurotoxins. About the prior owner: From the library of Roger Guillemin (1924-2024), a French-American neuroscientist, who joined the Salk Institute in 1970 at the invitation of Jonas Salk. In separate research laboratories, Guillemin and neuroscientist Andrew Schally (1926-2024) discovered the structures of Thyrotropin-releasing hormone (TRH) and Gonadotropin-releasing hormone (GnRH). They were jointly awarded the 1977 Nobel Prize in Physiology or Medicine for this discovery. In addition, Guillemin received awards from the National Academy of Sciences, 1974; the Canada Gairdner International Award, 1974; the Albert Lasker Award for Basic Medical Research, 1975; the Dickson Prize in Medicine, 1976; the Passano Award in Medical Sciences, 1976; the National Medal of Science, 1976; and from the American Academy of Arts and Sciences, 1977.
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