The Brain in Motion From Microcircuits to Global Brain Function Format: Hardcover

An evolutionary perspective—from lampreys to humans—on how the forebrain coordinates movement while the networks in the brainstem and spinal cord handle the execution.

All living creatures interact with their environment: even the most basic have a set of innate motor circuits they rely on to feed, locomote, fight, and flee. In The Brain in Motion, Sten Grillner describes the evolution of the motor repertoire of vertebrates, from protovertebrates to primates. With breadth and depth, Grillner explores how the brain uses the different microcircuits in the brainstem and spinal cord, coordinating them through commands from the forebrain. He also considers the normal function of the brain as a platform for understanding clinical conditions such as stroke, Parkinson´s and Huntington´s diseases, and spinal cord injury.

Grillner also explains in The Brain in Motion how the remarkable finding that the lamprey forebrain has all the components of the mammalian one has radically changed scientists’ views on the evolutionary origin of the vertebrate forebrain. We now know that the basic organization evolved 560 rather than 300 million years ago, as was previously thought. The forebrain, says Grillner, is like an orchestra conductor, while the microcircuits, with their reaching, grasping, posture, locomotion, and numerous other patterns of behavior, correspond to the members of the orchestra. The conductor determines when each will be called into action.

Providing an elegantly integrated perspective, The Brain in Motion is essential reading for anybody that works professionally with movement control and function and dysfunction, whether in basic research, clinically, or in the training of motor skills.

Sten Grillner is Distinguished Professor at the Karolinska Institute in Sweden and previous head of the Nobel Institute for Neurophysiology.