CD34+ a Novel Predictor of Vascular Events in Sickle Cell Disease: CD34+ Hematopoietic Stem Cell Count as a Novel Predictor of Vascular Event in Sickle Cell Disease Patients

Badawi, Rania; Aly, Nihal; Ellaboudy, Mohamed

ISBN 10: 6208118336 / ISBN 13: 9786208118334

Published by LAP LAMBERT Academic Publishing, 2024

About this Item

Seller Inventory # I-9786208118334

Bibliographic Details

• Title: CD34+ a Novel Predictor of Vascular Events in Sickle Cell Disease: CD34+ Hematopoietic Stem Cell Count as a Novel Predictor of Vascular Event in Sickle Cell Disease Patients
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2024
• Language: English
• ISBN 10: 6208118336
• ISBN 13: 9786208118334
• Binding: Soft cover
• Condition: New

About this title

Synopsis

Our aim is to evaluate circulating CD34 as a novel predictive marker of occurrence of vascular event in Children with Sickle Cell Disease in their steady state and relate levels to severity of VEs in the following 6 months.Patient and Methods: This study was an exploratory study, conducted at Pediatrics Hematology-Oncology Unit at Ain Shams University Children’s Hospital, where 50 children with sickle cell disease were enrolled at their steady state (defined as 2 months free from any Vascular Event prior to the study), aged 6 months - 16 years. Flow cytometry was done for quantification of circulating CD34+ at inclusion and compared to age and sex matched control and patients were followed up for 6 months for vascular events. Results: There is statistically significant higher level of CD34+ among SCD patients compared to age and sex matched control with p value < 0.001.Circulating CD34+ showed significantly higher level in patients who developed systemic vascular events after 6 months of follow up with p value 0.022. There was no statistically significant correlation between circulating CD34+ and severity of peripheral vascular events (or any need for hospitalization).