CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential

Language: English

Published by Springer Berlin Heidelberg Mai 2005, 2005

3540244441 / 9783540244448

Series: Book 9 of 322 - Current Topics in Microbiology and Immunology

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Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.

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This item is printed on demand - it takes 3-4 days longer - Neuware -The vertebrate immune system defends the organism against invading pathogens while at the same time being self-tolerant to the body's own constituents thus preserving its integrity. Multiple mechanisms work in concert to ensure self-tolerance. Apart from purging the T cell repertoire from auto-reactive T cells via negative selection in the thymus dominant tolerance exerted by regulatory T cells plays a major role in tolerance imposition and maintenance. Among the various regulatory/suppressive cells hitherto described, CD4+CD25+ regulatory T cells (Treg) and interleukin-10 producing T regulatory 1 (Tr1) cells have been studied in most detail and are the subject of most articles in this issue. Treg, also called 'natural' regulatory T cells, will be traced from their intra-thymic origin to the site of their action in peripheral lymphoid organs and tissues. The repertoire of Treg is clearly biased towards recognition of self-antigens, thereby potentially preventing autoimmune diseases such as gastritis and oophoritis. Regulatory T cells, however also control infections, allergies and tolerance to transplanted tissues and this requires their induction in the periphery under conditions which are not yet fully understood. The concept of dominant tolerance, by far not novel, will offer new insights and hopefully tools for the successful treatment of autoimmune diseases, improved cancer immunotherapy and transplant survival. The fulfillment of these high expectations will, however, require their unambiguous identification and a better understanding of their mode of action. 344 pp. Englisch.

Seller Inventory # 9783540244448

Title
CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential
Author
Elisabeth Suri-Payer
Publisher
Springer Berlin Heidelberg Mai 2005
Publication year
2005
Condition
Neu
Binding
Buch
Language
English
ISBN 10
3540244441
ISBN 13
9783540244448
Item weight
745 grams
Dimensions
241x160x26 mm
Series
Book 9 of 322: Current Topics in Microbiology and Immunology

BuchWeltWeit Ludwig Meier e.K.

Bergisch Gladbach, Germany

5-star seller

AbeBooks seller since January 11, 2012

Shipping rates from Germany to U.S.A.

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BuchWeltWeit Ludwig Meier e.K.

Germany