In biology, signal transduction is the transmission of information into and within the cell. Signal transduction events within a cell are often initiated from an extracellular cue. Current knowledge suggests that there are far fewer intracellular second messengers than extracellular cues. This means that a conserved core set of second messengers, including ions, small nucleotides, and lipids must be coordinated to pass the information from their point of origin to their audience receptors effectively. In many cases, signal transduction involves significant amplification. One of the best-understood and ubiquitous second messengers is ionic calcium (Ca2+). The knowledge surrounding the coding of information via Ca2+ signals has served as a template for studying other second messengers. Ca2+ signaling and intracellular Ca2+ homeostasis are highly complex and still incompletely understood. In this chapter, will we review the current knowledge of Ca2+ signaling. We will first provide a review of the general principles of Ca2+ signal transduction and examples of some of the major Ca2+-dependent cellular processes. Next, we will review the main sources of Ca2+ and the molecular effectors of Ca2+ signals. Then, we will provide some examples from the literature that illustrate how Ca2+ signaling works: how it can mediate signal amplification, how it encodes different types of signals, how it performs agonist-specific signals as well as function-specific signals, signal integration and co-incidence detection, and how it can cross-talk with other second messenger signaling events. Throughout this chapter, we will use Ca2+ as an example of a prototypical coded second messenger, since it is clear that much of the complexity of Ca2+ signaling likely applies to many of the other known second messengers.

Table of Contents: General Introduction / Sources of Ca2+ Signals / Ca2+-Dependent Processes: From Highly Specialized to Ubiquitous Cellular Roles / Major Ca2+-Signaling Effectors / Ca2+ Signal Coding / Acknowledgments / Bibliography / Titles of Related Interest

About the Author

Department of Cellular and Physiological Sciences, University of British Columbia

"About this title" may belong to another edition of this title.

Store Description

I mainly carry imported books from South East Asia / South Asia for readers of all Age Groups.

Visit Seller's Storefront

Seller's business information

PLETOS INC
6931 51st Avenue, WOODSIDE, Woodside, NY, 11377, U.S.A.

Sale & Shipping Terms

Terms of Sale

We accept return for those books which are received damaged. Though we take appropriate care in packing to avoid such situation.

Shipping Terms

Shipping rates within U.S.A.

Shipping rates within U.S.A.
Order quantity	12 to 19 business days	12 to 14 business days
First item	US$ 3.99	US$ 6.99

Delivery times are set by sellers and vary by carrier and location. Orders passing through Customs may face delays and buyers are responsible for any associated duties or fees. Sellers may contact you regarding additional charges to cover any increased costs to ship your items.