Calcium Entry Blockers in Cardiovascular and Cerebral Dysfunctions (Developments in Cardiovascular Medicine)

Theophile Godfraind; Arnold G. Herman; Donald Wellens (editors)

ISBN 10: 0898386586 / ISBN 13: 9780898386585

Published by Martinus Nijhoff, 1984

About this Item

Ex-library with the usual features. The interior is clean and tight. Binding is good. Cover shows light wear. 322 pages.

Seller Inventory # 122592

Bibliographic Details

• Title: Calcium Entry Blockers in Cardiovascular and Cerebral Dysfunctions (Developments in Cardiovascular Medicine)
• Publisher: Martinus Nijhoff
• Publication Date: 1984
• Language: English
• ISBN 10: 0898386586
• ISBN 13: 9780898386585
• Binding: Hard Cover
• Condition: Acceptable
• Dust Jacket Condition: No Jacket
• Book Type: Ex-Library

About this title

Synopsis

2 The free internal Ca+ concentration in human red cells is set according to the leak­ 2 and-pump principle: There is a finite passive Ca+ influx at the physiological 2 2 Ca+ -gradient across the membrane which is compensated by Ca+ pumping in the outward direction with a rate given by the degree of saturation of the A TP-fuelled Ca­ 2 pump at the steady-state internal Ca+ concentration. Simons (1982) recently devised a method allowing the measurement of the steady­ 2 2 state internal Ca+ concentration. Cells are suspended in media of different Ca+ con­ 2 2 tent whose Ca+ concentration is monitored by a Ca+ -selective electrode. When the cells are lysed (by digitonin) there is an upward or downward deflection of the elec­ 2 trode signal. At the point of zero deflection, the cellular Ca+ concentration equals that 2 of the medium. The result is, that in fresh human red blood cells the Ca+ concentra­ tion is ;;;; O.4,uM (this is an upper estimate; the true value may be considerably lower).

Language Notes

Text: English
Introduction: French, German, Spanish