Cancer Cell Lines Part 1

Language: English

Published by Springer Okt 1998, 1998

0792351436 / 9780792351436

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Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH

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Neuware - Continuous cell lines derived from human cancers are the most widely used resource in laboratory-based cancer research. The first 3 volumes of this series on Human Cell Culture are devoted to these cancer cell lines. The chapters in these first 3 volumes have a common aim. Their purpose is to address 3 questions of fundamental importance to the relevance of human cancer cell lines as model systems of each type of cancer: 1. Do the cell lines available accurately represent the clinical presentation 2. Do the cell lines accurately represent the histopathology of the original tumors 3. Do the cell lines accurately represent the molecular genetics of this type of cancer The cancer cell lines available are derived, in most cases, from the more aggressive and advanced cancers. There are few cell lines derived from low grade organ-confined cancers. This gap can be filled with conditionally immortalized human cancer cell lines. We do not know why the success rate for establishing cell lines is so low for some types of cancer and so high for others. The histopathology of the tumor of origin and the extent to which the derived cell line retains the differentiated features of that tumor are critical. The concept that a single cell line derived from a tumor at a particular site is representative of tumors at that site is naïve and misleading.

Seller Inventory # 9780792351436

Title
Cancer Cell Lines Part 1
Author
John Masters
Publisher
Springer Okt 1998
Publication year
1998
Condition
Neu
Binding
Buch
Language
English
ISBN 10
0792351436
ISBN 13
9780792351436
Item weight
629 grams
Dimensions
241x160x22 mm

AHA-BUCH GmbH

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