Cancer Chemotherapy and Biotherapy: Principles and Practice

Thoroughly revised and enlarged, this book presents a comprehensive, detailed description of the properties and clinical use of anticancer drugs. It provides the latest information on all aspects of drug mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. Particular emphasis is placed on the rationale for the use of drugs in specific schedules and combinations, and guidelines are provided by dose adjustment in particular situations. This edition includes chapters on Endocrine Therapies, Antifolates, 5-Fluoropyrimidines, Cytidine Analogues, Purine Antimetabolites, Hydroxyurea, Antimicrotubule Agents, Alkylating Agents, Antitumor Antibiotics, Anthracyclines, Topoisomerase II Inhibitors, Enzyme Therapy and Anti-HIV Drugs.

New England Journal of Medicine, Volume 18, Issue 355 -- "The editors have taken on the Herculean task of melding chemotherapy and biologic therapy, with an emphasis on clinical relevance. To a great degree, they have accomplished their goal. The chapters are up to date, considering the rapid changes in the field. There is extensive use of illustrations and tables, and summary tables in each chapter reinforce the central themes. The discussion of antibody therapy provides an excellent overview of the current state of functional mechanisms. This textbook will continue to be a resource for clinical oncologists, and it remains one of the essential readings for medical oncologists in training. The editors and contributors should be complimented on the results of their labors, which improve on their previous exceptional efforts."