Cancer Chemotherapy and Selective Drug Development

Harrap, K. R.; Davis, W.; Calvert, Alan Hilary

ISBN 10: 089838673X / ISBN 13: 9780898386738

Published by Kluwer Academic Publishers, 1984

About this Item

Proceedings of the 10th Anniversary Meeting of the Coordinating Committee for Human Tumour Investigations, Brighton, England (24-28 October 1983) Series: Developments in Oncology. Num Pages: 585 pages, biography. BIC Classification: MJCL. Category: (P) Professional & Vocational; (UP) Postgraduate, Research & Scholarly. Dimension: 234 x 156 x 33. Weight in Grams: 1034. . 1984. Hardback. . . . .

Seller Inventory # V9780898386738

Bibliographic Details

• Title: Cancer Chemotherapy and Selective Drug Development
• Publisher: Kluwer Academic Publishers
• Publication Date: 1984
• Language: English
• ISBN 10: 089838673X
• ISBN 13: 9780898386738
• Binding: Hardcover
• Condition: New

About this title

Synopsis

Over the past 30 years many significant advances have been made in the management of a number of disseminated malignant diseases. The prognosis for diseases such as childhood leukaemia, choriocarcinoma and Hodgkin's disease has gradually been transformed as better anti tumour agents have become available and their clinical use has been refined. During the past 10 years the advent of new agents, particularly cisplatin, bleomycin and the podophyllotoxins, has allowed the cure of disseminated testicular tumours. This degree of success has not, however, been achieved in the case of a number of other common cancers. Ovarian carcinoma is tantalisingly chemo-sensitive and although there are long term survivors from disseminated disease, these are only a small proportion of the total. Breast cancer, although "sensitive" to a multitude of drugs appears to have yielded neither survival benefit, nor cure to the efforts of therapists, while tumours such as those of the colon remain stubbornly unresponsive. Against this backcloth it is apparent that additional more selective treatments are needed if further impact is to be made on the problem of cancer. The development of such agents requires the integration of a multidisciplinary effort encompassing the fields of chemistry, biology and medicine. This symposium provided a forum for clinical and preclinical sCientists, where current aspects of cancer treatment were reviewed and approaches to the development of a new generation of more selective anticancer drugs discussed.