Cancer Genome and Tumor Microenvironment

Language: English

Published by Springer New York, Copernicus Dez 2009, 2009

1441907106 / 9781441907103

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This item is printed on demand - Print on Demand Titel. Neuware -Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late ¿80s-early ¿90s, neoplastic growth was described largely as an imbalance between net cell accumulation and loss, brought about through mutations in cancer genes. In the last ten years, a more holistic understanding of cancer has slowly emerged, stressing the importance of interactions between neoplastic and various stromal components: extracellular matrix, basement membranes, fibroblasts, endothelial cells of blood and lymphatic vessels, tumor-infiltrating lymphocytes, etc. The commonly held view is that changes in tumor microenvironment are ¿soft-wired¿, i.e., epigenetic in nature and often reversible. Yet, there exists a large body of evidence suggesting that well-known mutations in cancer genes profoundly affect tumor milieu. In fact, these non-cell-autonomous changes might be one of the primary reasons such mutations are preserved in late-stage tumors.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 512 pp. Englisch.…

Seller Inventory # 9781441907103

Title
Cancer Genome and Tumor Microenvironment
Author
Andrei Thomas-Tikhonenko
Publisher
Springer New York, Copernicus Dez 2009
Publication year
2009
Condition
Neu
Binding
Buch
Language
English
ISBN 10
1441907106
ISBN 13
9781441907103
Item weight
1,022 grams
Dimensions
241x160x36 mm

buchversandmimpf2000

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