Cancer Stem Cells: Basic Concept and Therapeutic Implications

This book comprehensively reviews the role of cancer stem cells (CSCs) in cancer initiation, progression, and resistance to anticancer therapies. The initial chapters examine the methods and procedure of the detection, isolation, and characterization of CSCs. It also introduces various epigenetic pathways that contribute to cancer initiation and tumorigenesis, particularly regarding the maintenance and survival of CSCs.  It also explores the role of CSCs metabolism and the mechanisms of metabolic plasticity of CSCs in cancer biology. Further, it also presents the implications of CSCs on the origin of tumor heterogeneity and on heterogeneity of the therapeutic response.  Towards the end, this book highlights the different immunotherapeutic approaches targeting CSCs with the potential of strongly improving cancer outcomes. This book offers a broad framework to scientists and clinicians into the state-of-the-art knowledge on cancer stem cell biology and highlights their therapeutic implications.

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Dr Farhadul Islam is an Associate Professor at the Department of Biochemistry and Molecular Biology, University of Rajshahi, Bangladesh. His research interests are focused on cancer biology, cancer genetics, epigenetics, drug development, and identification of the molecular markers in various cancers.  He has more than 10 years of teaching and research experience in Cell Biology, Molecular Biology, Biochemistry, Molecular Oncology, Cancer Pathology, Drug Development and Discovery.  He is serving as an Associate Editor of BMC Cancer, Editorial Broad Member of Anticancer Agents and Medicinal Chemistry and Guest Editor of Frontiers in Endocrinology and Frontiers in Oncology. He has been awarded several prestigious awards, including Academic Excellence Award and Chancellor’s medal, Early Career Researcher award from Griffith University, Australia. He was also awarded Dean’s Award from Faculty of Science, University of Rajshahi, Bangladesh for his outstanding research performance. He has published more than 70 research articles in peer-reviewed international journals and has authored or co-authored several book chapters and book on cancer pathogenesis. He also is a member of many national and international scientific societies and organizations.