Cell Cycle Control of Mammalian Neural Stem Cells | Putting a Speed Limit on G1

Federico Calegari (u. a.)

ISBN 10: 3838381696 / ISBN 13: 9783838381695

Published by LAP LAMBERT Academic Publishing, 2010

About this Item

Cell Cycle Control of Mammalian Neural Stem Cells | Putting a Speed Limit on G1 | Federico Calegari (u. a.) | Taschenbuch | Englisch | 2010 | LAP LAMBERT Academic Publishing | EAN 9783838381695 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

Seller Inventory # 107489442

Bibliographic Details

• Title: Cell Cycle Control of Mammalian Neural Stem Cells | Putting a Speed Limit on G1
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2010
• Language: English
• ISBN 10: 3838381696
• ISBN 13: 9783838381695
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 5D millimeters 220 millimeters width by 150 millimeters height by 5 millimeters depth
• Weight: 119 grams
• Seller catalogs:
  • Bücher

About this title

Synopsis

The potential to unlimitedly expand and generate differentiated cell types is a key feature of somatic stem cells. Within the nervous system, cellular and environmental determinants tightly control the expansion and differentiation of neural stem cells. Importantly, a number of studies indicate that changes in cell cycle length can influence development and physiopathology of the nervous system, and may have played a role during evolution of the mammalian brain. Specifically, it has been suggested that the length of G1 can directly influence the differentiation of neural precursors. This has prompted the proposal of a model to explain how manipulation of G1 length can be used to expand neural stem cells. If validated in non-neural systems, this model may provide the means to control the proliferation vs. differentiation of somatic stem cells, which will represent a significant advance in the field.

About the Author

Calegari Federico is group leader of the DFG-Funded Center and Cluster of Excellence for Regenerative Therapies, Dresden, Germany. Paolo Salomoni is Brian Cross Professorial Research Associate at the UCL-Cancer Institute. He leads the newly established Samantha Dickson Brain Cancer Unit, London, UK