Cell Engineering Of Human Bone | Effect of Transforming Growth Factor Beta (TGF-¿) on Wound Healing of Bone

Farshid Sefat

ISBN 10: 3639516745 / ISBN 13: 9783639516746

Published by Scholars' Press, 2013

About this Item

Cell Engineering Of Human Bone | Effect of Transforming Growth Factor Beta (TGF-¿) on Wound Healing of Bone | Farshid Sefat | Taschenbuch | 236 S. | Englisch | 2013 | Scholars' Press | EAN 9783639516746 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

Seller Inventory # 105585800

Bibliographic Details

• Title: Cell Engineering Of Human Bone | Effect of Transforming Growth Factor Beta (TGF-¿) on Wound Healing of Bone
• Publisher: Scholars' Press
• Publication Date: 2013
• Language: English
• ISBN 10: 3639516745
• ISBN 13: 9783639516746
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 15D millimeters 220 millimeters width by 150 millimeters height by 15 millimeters depth
• Weight: 369 grams
• Seller catalogs:
  • Bücher

About this title

Synopsis

Bone repair is modulated by different stimuli. There is evidence that the Transforming Growth Factor-beta (TGF-β) super-family of cytokines have significant effects on bone structure by regulating the replication and differentiation of chondrocytes, osteoblasts and osteoclasts. This book aimed at determining the role of the TGF-βs, Collagen type I, Fibronectin and Laminin in bone cell behaviour. To do this MG-63 bone cells were used to examine cell adhesion and alignment to different micro-contact printed ECM protein patterns of different widths. The study also aimed at examining how various TGF-β isomers (TGF-β1, 2 and 3) and their solvent and carrier (HCl and BSA, respectively) effected cell surface interactions, cell morphology, cell proliferation and integrin expression. Finally, this study also aimed at examining how the TGF-βs and their solvent and carrier influenced wound closure in an in vitro wound closure model and how TGF-βs influence ECM secretion and integrin expression.

About the Author

Dr. Farshid Sefat is a Post Doctorate Research Assistant at the University of Sheffield (United Kingdom). He received his bachelor degree in Medical Engineering from University of Bradford (UK), MSc. in Cell and Tissue Engineering from Keele University (UK) and PhD in Bone Tissue Engineering from University of Bradford (UK).