Cell-Extracellular Matrix Interactions in Cancer

ISBN 10: 1441908137 / ISBN 13: 9781441908131

Published by Springer, 2009

About this Item

Print on Demand pp. 328 28 Illus. (17 Col.).

Seller Inventory # 6695122

Bibliographic Details

• Title: Cell-Extracellular Matrix Interactions in Cancer
• Publisher: Springer
• Publication Date: 2009
• Language: English
• ISBN 10: 1441908137
• ISBN 13: 9781441908131
• Binding: Hardcover
• Condition: New

About this title

Synopsis

Cancer was thought to originate from alterations in intercellular signaling that resulted in the transformation of cells, their uncontrolled proliferation and metastasis. There is now an increasing body of evidence demonstrating that the surrounding matrix and cell-matrix interactions are also major players in this process. Cells adhere and receive signals from various extracellular matrices via transmembrane receptors, the best known of which are the heterodimeric glycoproteins, integrins.

From the Back Cover

Cells require interactions with extracellular matrix (ECM) components in order to undergo normal morphogenesis with respect to organogenesis. ECM plays a significant role in regulating numerous cellular functions, like cell shape, adhesion, migration, proliferation, polarity, differentiation and apoptosis. In pathological conditions such as cancer, increased synthesis of certain ECM components and/or increased breakdown with consequent generation of ECM cleavage products can contribute to cancer growth and progression. That many growth factors (i.e. FGF, VEGF) are stored in the ECM milieu and are released upon protease-dependent cleavage further confirms the importance of ECM in regulating cell functions.

Cell-Extracellular Matrix Interactions in Cancer describes how ECM creates a niche for tumor formation and the contribution of ECM components and their respective receptors in the development and spread of cancer.