Cell Fate Analysis of Embryonic Stem Cell Neuronal Differentiation | Molecular comparison between in vitro neuronal differentiation and in vivo brain development

Publisher

LAP Lambert Academic Publishing

Publication Date

2012

Language

English

ISBN 10

3659302481

ISBN 13

9783659302480

Binding

Taschenbuch

Condition

Neu

Dimensions

Weight

244 grams

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Synopsis

Embryonic stem (ES) cells are a powerful source for generating potentially unlimited numbers of specialized cells. An important progress has been made to differentiate pluripotent stem cells toward different cell populations, in particular toward neuronal populations owing to their potential use in neurodegenerative diseases. However, ES cell based approaches face a number of challenges that hindered their application in biology and regenerative medicine. This book, therefore, present studies addressing these challenges by establishing a large panel of neural markers and region specific transcription factors linked to embryonic brain development in vivo. These markers were used to monitor and compare the in vitro and in vivo ES cell differentiation toward telencephalic and mesencephalic phenotypes. These studies allow a further optimization of the human and mouse ES cell culture protocols in order to obtain specific neuronal population as a source for neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. The book should be useful for neuroscientists, students, or anyone else interested in stem cells and regenerative medicine.

About the Author

Studied Biology at Lebanese University. Then got a Master 2 degree in Physiology, Molecular and Cellular Biology at Poitiers, France. In 2012, I obtained a PhD in Neuroscience (neural stem cell differentiation) at Medical University Innsbruck -Austria where I currently work as a research assistant on social interaction and drug of abuse.

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