Cell-To-Cell Communication Cell-Atlas: Visual Biology in Oral Medicine

The deepest understanding of the cells of the oral system will be found in decoding their communication and seeing how it is regulated. Once we have understood their language, clinicians might be able to talk to cells and control their action. This book by 47 world-renowned experts – for each chapter at least one clinician and one basic scientist – highlights a reliable and actual state of research regarding this topic that quickly moves forward. Beyond the classic cell types addressed in the first part of the book and visualized by colored scanning electron microscopic (SEM) images, organ systems or model systems of cell-to-cell communication of a more generic type are presented in four additional chapters in the second part.This book – accompanied by an augmented reality (AR) app that allows you to experience the process of bone resorption virtually – should help to open the vision of how we can regenerate tissues and heal diseases by controlling the language of the cells, and shows us the direction in which research and therapy will go in the future.Part 1: Cell Atlas of the Oral System “A to Z” Ameloblasts (R. J. Miron, A. Lussi) B-Cells / T-Cells (J. Konkel, I. Chapple) Cementoblasts & Cementocytes (B. L. Foster, M. Sanz) Chondrocytes and Fibrochondrocytes (D. S. Nedrelow, M. S. Detamore, M. E. Wong) Dental Stem Cells: Developmental Aspects (J. Krivanek, K. Fried) Epithelial Cells (V.-J. Uitto, U. K. Gursoy) Fibroblasts (G. Pompermaier Garlet, D. S. Thoma) Macrophages (J. CW. Wang, W. V. Giannobile) Microvascular Cells: Endothelium and Pericytes (A. Banfi, S. Kühl) Myocytes (S. W. Herring, S. Kiliaridis) Nerve Cells (S. Bae Oh, Pa Reum Lee, D. A. Ettlin) Odontoblasts (D. D. Bosshardt, P. R. Schmidlin) Osteoblasts (F. E. Weber, B. Lethaus) Osteoclasts / Odontoclasts (R. Nishimura, H. Terheyden) Osteocytes (R. Gruber, B. Stadlinger) Polymorphonuclear Cells (Neutrophils) (J. Deschner, S. Jepsen) Salivary Acinar Cells (G. B. Procter, A. Vissink) Part 2: Cellular Interactions – Insights and Outlooks Oral Microbiota, Biofilms and Their Environment (N. Bostanci, G. N. Belibasakis) Mesenchymal Stromal Cells: Therapeutic Aspects (Q. Vallmajo-Martin, J. S. Marschall, E. Avilla-Royo, M. Ehrbar) Model Systems for Investigation of Cell-to-Cell Communication (P. Korn, M. Gelinsky) Linking Molecular Function with Tissue Structure in the Oral Cavity (C. Porcheri, C. T. Meisel, T. A. Mitsiades)

Prof Reinhard Gruber holds a PhD in Biotechnology and has worked at the University Clinic of Dentistry at the Medical University of Vienna since 1999. He was Vice Director of the Curriculum for Dentistry and founded the PhD program “Bone and Joint Regeneration.” Prof Gruber was active as a visiting scientist at the Bone Tissue Engineering Center of Carnegie Mellon University in Pittsburgh and at the Dental School of the University of Michigan. From 2012 to 2014, he headed the Oral Cell Biology Laboratory at the Dental Clinics of the University of Bern, to which he is still affiliated. In October 2014, Prof Gruber was appointed Professor of Oral Biology at the Medical University of Vienna. He is a trustee of the Osteology Foundation, a member of the ITI Research Committee, and a scientific advisor to the Austrian Society for Bone and Mineral Metabolism. From 2008 to 2015, Prof Gruber was Editor-in-Chief of the International Journal of Stomatology & Occlusion Medicine and the Journal of Stomatology of the Austrian Society of Dental, Oral and Maxillofacial Medicine. He is currently Associate Editor of Clinical Oral Implants Research and the International Journal of Oral & Maxillofacial Implants, and serves on several editorial boards, including the Journal of Dental Research, Periodontology 2000, and Clinical Oral Investigations. Prof Gruber and his team have published over 250 original articles and reviews in international journals and numerous book chapters in the field of regenerative dentistry.

Bernd Stadlinger studied medicine and dentistry at the universities of Erlangen, Vienna, and Dresden from 1996 to 2006. He trained as a specialist in oral and maxillofacial surgery at the University Hospital Dresden and habilitated in 2011 with the topic “Functional biomaterials to influence maxillofacial bone healing.” In July 2011, he became senior physician in the Department of Oral and Maxillofacial Surgery – Clinic for Oral Surgery at the University of Zurich. After his rehabilitation at the University of Zurich, he became a specialist in oral surgery in 2013, and has been Head Physician and Head of Dento-Maxillofacial Radiology since December 2015. Bernd Stadlinger is a board member of the Swiss Society for Oral Surgery and Stomatology (SSOS) and the Swiss Association for Maxillofacial Surgery and Oral Diseases (SAKM). The focus of his scientific work is the interaction between biomaterials and bone, in particular the coating of implants with different organic components to accelerate peri-implant bone healing. His other area of interest is imaging techniques and the implementation of digital treatment methods. In the field of teaching, he is the author of various computer-animated science films and is actively involved in the integration of modern media into university teaching, for which he has received numerous science and teaching awards.

Prof Dr med dent Hendrik Terheyden is head physician at the Department of Oral and Maxillofacial Surgery, Helios Hospital in Kassel, Germany. Hendrik Terheyden studied dentistry from 1983 to 1989 at the University of Kiel. In 1989, he was a staff physician for the Navy in Flensburg. From 1989-1992 he studied human medicine at the University of Kiel. In 1993 he became a specialist in oral surgery and in 1997 a specialist in oral and maxillofacial surgery with the additional title of plastic surgery (1999). In 1999 he completed his PhD (Habilitation) at the University of Kiel. He received the Wassmund Prize of the German Society for Oral and Maxillofacial Surgery (DGMKG). In 2004, he became an adjunct professor at Kiel University. From 2009 to 2012, he was president of the German Society for Implantology, and from 2017 to 2019, he was Chairman of the Oral and Maxillofacial Surgery Working Group of the German Society for Oral and Maxillofacial Surgery (DGZMK). Since 2006, Prof Terheyden has been section editor of the International Journal of Oral & Maxillofacial Surgery, and since 2012 he has been editor in chief of the International Journal of Implant Dentistry. Since 2021, he has served on the board of the Working Group of Senior Hospitalists of the German Society for Oral and Maxillofacial Surgery.