Chemically-Induced DNA Damage, Mutagenesis, and Cancer

ISBN 10: 3038971294 / ISBN 13: 9783038971290

Published by Mdpi AG, 2018

About this Item

PRINT ON DEMAND pp. 274.

Seller Inventory # 18379783077

Bibliographic Details

• Title: Chemically-Induced DNA Damage, Mutagenesis, and Cancer
• Publisher: Mdpi AG
• Publication Date: 2018
• Language: English
• ISBN 10: 3038971294
• ISBN 13: 9783038971290
• Binding: Soft cover
• Condition: New

About this title

Synopsis

Human cancers frequently arise from exposure to chemicals, although radiation, oxidation, and genetic factors play critical roles as well. DNA damage by these agents in a cell is an important first step in the process of carcinogenesis. DNA repair processes have evolved to repair these damages. However, the replication of damaged DNA may occur frequently prior to repair, resulting in gene mutations and the generation of altered proteins. Mutations in an oncogene, a tumor-suppressor gene, or a gene that controls the cell cycle give rise to a clonal cell population with an advantage in proliferation. The complex process of carcinogenesis includes many such events, but has been generally considered to be comprised of the three main stages known as initiation, promotion, and progression, which ultimately give rise to the induction of human cancer. The articles published in this book entitled "Chemically-Induced DNA Damage, Mutagenesis, and Cancer" provide an overview on the topic of the "consequence of DNA damage" in the context of human cancer with their challenges and highlights.