Chinna Reddy Palem: Development Of Bilayered Mucoadhesive Buccal Patches For Felodipine: In Vitro, Ex Vivo And In Vivo Characterization

Palem, Chinna R.; Madhusudan Rao, Y.; Vamshi Vishnu, Y.; Palem, Chinna R.; Madhusudan Rao, Y.; Vamshi Vishnu, Y.

ISBN 10: 3843376565 / ISBN 13: 9783843376563

Published by Lap Lambert Academic Publishing, 2010

About this Item

84 pages. 8.66x5.91x0.19 inches. In Stock.

Seller Inventory # __3843376565

Bibliographic Details

• Title: Chinna Reddy Palem: Development Of Bilayered Mucoadhesive Buccal Patches For Felodipine: In Vitro, Ex Vivo And In Vivo Characterization
• Publisher: Lap Lambert Academic Publishing
• Publication Date: 2010
• Language: English
• ISBN 10: 3843376565
• ISBN 13: 9783843376563
• Binding: Paperback
• Condition: Brand New
• Weight: 0.17 kilograms

About this title

Synopsis

Over the decades, peroral delivery has been the popular route of administration for the majority of therapeutic agents targeting systemic delivery. Oral administration generally leads to extensive presystemic elimination, which may include GI degradation, metabolism, or first-pass clearance via the liver. Transmucosal drug delivery offers attractive alternative routes for administration of drugs and may avoid the significant drawbacks of peroral and parenteral administration. These routes of administration bypass first pass metabolism by delivering drug directly into the systemic circulation. Buccal drug delivery offers several advantages over the oral route and other alternative routes of drug administration. The membranes that line the oral cavity are readily accessible, robust, and exhibit fast cellular recovery following local stress or damage and are exposed to various exogenous compounds. Properly constructed oral transmucosal drug delivery systems are easy and painless to administer and well accepted by the patient. Precise localization of the dosage form is possible and there is the ability to terminate delivery when required (e.g. because of toxicity).

About the Author

Mr.Chinna Reddy Palem is currently pursuing his Ph.D under the supervision of Prof. Y.M.Rao in UCPSc, KU. He completed B.Pharm from KU and M.Pharm from BVU. He secured All India 2nd Rank in BVUCET-2004.He is an awardee of CSIR Travel grant and Amgen travel award for best poster,FIP PSWC-2010, New Orleans,USA.More than 20 publications in his credit.