Chlamydia pneumoniae Lung Infection in Two Inbred Mouse Strains

Chengming Wang

ISBN 10: 383835091X / ISBN 13: 9783838350912

Published by LAP LAMBERT Academic Publishing Mär 2010, 2010

About this Item

This item is printed on demand - Print on Demand Titel. Neuware -Infections with Chlamydia pneumoniae have been associated with chronic inflammatory diseases, but the influences of multiple factors are not well understood. A multivariate experimental design investigated the major factors that influence disease, chlamydial lung burden, and transcript levels: i) host genetics, ii) pre-challenge immunity, iii) time after challenge infection, iv) dietary protein content, v) dietary antioxidant content. The combined effects of mouse strain, immune status, and time after challenge inoculation resulted in opposite outcomes for lung disease and elimination of C. pneumoniae, while dietary protein and antioxidant content had little overall influence. A simple best-fit partial least square regression model using day-3 Tim3, GATA3, and arginase 2 transcript concentrations predicted 85% of the day-10 disease and 72% of the day-10 C. pneumoniae lung load. This book has elucidated general mechanisms of chlamydial pathogenesis, and clearly supports the concept that host-dependent levels of early Th1 and Th2 responses, and their balance, significantly correlated with late disease and pathogen load of C. pneumoniae lung infections.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 116 pp. Englisch.

Seller Inventory # 9783838350912

Bibliographic Details

• Title: Chlamydia pneumoniae Lung Infection in Two Inbred Mouse Strains
• Publisher: LAP LAMBERT Academic Publishing Mär 2010
• Publication Date: 2010
• Language: English
• ISBN 10: 383835091X
• ISBN 13: 9783838350912
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 7D millimeters 220 millimeters width by 150 millimeters height by 7 millimeters depth
• Weight: 191 grams

About this title

Synopsis

Infections with Chlamydia pneumoniae have been associated with chronic inflammatory diseases, but the influences of multiple factors are not well understood. A multivariate experimental design investigated the major factors that influence disease, chlamydial lung burden, and transcript levels: i) host genetics, ii) pre-challenge immunity, iii) time after challenge infection, iv) dietary protein content, v) dietary antioxidant content. The combined effects of mouse strain, immune status, and time after challenge inoculation resulted in opposite outcomes for lung disease and elimination of C. pneumoniae, while dietary protein and antioxidant content had little overall influence. A simple best-fit partial least square regression model using day-3 Tim3, GATA3, and arginase 2 transcript concentrations predicted 85% of the day-10 disease and 72% of the day-10 C. pneumoniae lung load. This book has elucidated general mechanisms of chlamydial pathogenesis, and clearly supports the concept that host-dependent levels of early Th1 and Th2 responses, and their balance, significantly correlated with late disease and pathogen load of C. pneumoniae lung infections.