Chlamydia pneumoniae Lung Infection in Two Inbred Mouse Strains

Language: English

Published by LAP LAMBERT Academic Publishing Mär 2010, 2010

383835091X / 9783838350912

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This item is printed on demand - Print on Demand Titel. Neuware -Infections with Chlamydia pneumoniae have been associated with chronic inflammatory diseases, but the influences of multiple factors are not well understood. A multivariate experimental design investigated the major factors that influence disease, chlamydial lung burden, and transcript levels: i) host genetics, ii) pre-challenge immunity, iii) time after challenge infection, iv) dietary protein content, v) dietary antioxidant content. The combined effects of mouse strain, immune status, and time after challenge inoculation resulted in opposite outcomes for lung disease and elimination of C. pneumoniae, while dietary protein and antioxidant content had little overall influence. A simple best-fit partial least square regression model using day-3 Tim3, GATA3, and arginase 2 transcript concentrations predicted 85% of the day-10 disease and 72% of the day-10 C. pneumoniae lung load. This book has elucidated general mechanisms of chlamydial pathogenesis, and clearly supports the concept that host-dependent levels of early Th1 and Th2 responses, and their balance, significantly correlated with late disease and pathogen load of C. pneumoniae lung infections.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 116 pp. Englisch.…

Seller Inventory # 9783838350912

Title
Chlamydia pneumoniae Lung Infection in Two Inbred Mouse Strains
Author
Chengming Wang
Publisher
LAP LAMBERT Academic Publishing Mär 2010
Publication year
2010
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
383835091X
ISBN 13
9783838350912
Item weight
191 grams
Dimensions
220x150x7 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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