Cholinergic modulation of synaptic transmission and plasticity | A Ph.D. thesis on the cortical action of acetylcholine

Nicola Kuczewski

ISBN 10: 3639218205 / ISBN 13: 9783639218206

Published by VDM Verlag Dr. Müller, 2009

About this Item

Cholinergic modulation of synaptic transmission and plasticity | A Ph.D. thesis on the cortical action of acetylcholine | Nicola Kuczewski | Taschenbuch | Englisch | VDM Verlag Dr. Müller | EAN 9783639218206 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

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Bibliographic Details

• Title: Cholinergic modulation of synaptic transmission and plasticity | A Ph.D. thesis on the cortical action of acetylcholine
• Publisher: VDM Verlag Dr. Müller
• Publication Date: 2009
• Language: English
• ISBN 10: 3639218205
• ISBN 13: 9783639218206
• Binding: Taschenbuch
• Condition: Neu
• Seller catalogs:
  • Bücher

About this title

Synopsis

The physiological and cognitive states of the brain are influenced by variations in the activity of the cholinergic systems. For example, changes in the levels of acetylcholine have been associated with arousal/sleep cycle, sustained and focal attention. The importance of acetylcholine action on brain physiology is highlighted by the fact that a deficit of cholinergic transmission impairs learning and cellular plasticity and is involved in brain pathology such as Alzheimer diseases. Cholinergic activity exerts is action by modifying the extracellular cortical concentration of acetylcholine; here will be discussed several experimental data suggesting that a selective activation of the different subtypes of cholinergic receptors, produced by the modification in cortical acetylcholine release, is capable to modulate the dynamics of cortical activity and to affects the way in witch synaptic connections are modified by experience. Will be further discussed how such property could affects the brain cognitive states and the mnemonic processes that are associated whit high or low level of activation of the cholinergic system.