Clinical Epidemiology Principles, Methods, and Applications for Clinical Research

Now updated with new data and examples throughout, Clinical Epidemiology: Principles, Methods, and Applications for Clinical Research, Second Edition is a comprehensive resource that introduces the reader to the basics of clinical epidemiology and explores the principles and methods that can be used to obtain quantitative evidence on the effects of interventions and on the diagnosis, etiology, and prognosis of disease. The everyday challenges of clinical research and the quantitative knowledge required to practice medicine are also examined, making this book a valuable reference for both graduate and undergraduate students in medicine and related disciplines, as well as for professionals involved in the design and conduct of clinical research.

Diederick (Rick) E. Grobbee, MD, PhD (1957) was trained in medicine in Utrecht and, after a residency in internal medicine, obtained a PhD in epidemiology at Erasmus University in Rotterdam. His education was continued at McGill University in Montreal and as a visiting Associate Professor at Harvard University School of Public Health. He spent nearly a decade at Erasmus, where he headed the cardiovascular epidemiology group and was appointed Professor of Clinical Epidemiology. He subsequently moved to the University Medical Center Utrecht, to become Professor of Clinical Epidemiology and founder of the Julius Center for Health Sciences and Primary Care of which he served as a Chairman for the next 14 years. He holds honorary appointments at Sydney University and the University of Malaya in Kuala Lumpur. In 2010 he was appointed Distinguished University Professor of International Health Sciences and Global Health at Utrecht University, where he also is Program Director of the international MSc and PhD Epidemiology Program. He is a fellow of the Royal Netherlands Academy of Sciences and chairs its Medical Section and Medical Advisory Council. He is Editor-in-Chief of the European Journal of Preventive Cardiology. His teaching experience includes courses on clinical epidemiology and clinical research methods to various audiences in several countries.

Arno W. Hoes, MD, PhD (1958) studied medicine at the Radboud University in Nijmegen. He obtained his PhD degree in clinical epidemiology at the Erasmus Medical Center in Rotterdam. He was further trained in clinical epidemiology at the London School of Hygiene and Tropical Medicine. In 1991, he was appointed assistant professor of clinical epidemiology and general practice at both the department of epidemiology and the department of general practice at the Erasmus Medical Center. At the latter department, he headed the research line, “cardiovascular disease in primary care.” In 1996, he moved to the Julius Center for Health Sciences and Primary Care of the University Medical Center in Utrecht, where he was appointed professor of clinical epidemiology and primary care in 1998. Since 2010, he is the Chair of the Julius center. Most of his research current activities focus on the (early) diagnosis, prognosis and therapy of common cardiovascular diseases.' His teaching experience includes courses on clinical epidemiology, diagnostic research, case-control studies, drug risk assessment, and cardiovascular disease. His is a member of the Dutch Medicines Evaluation Board, the Health Council of the Netherlands, and of the Editorial Board of several medical journals.