Clinical Trials in Heart Disease

Understanding clinical trials and the resulting outcomes is important to understanding the management of cardiovascular health. This new edition (a companion to Braunwald's Heart Disease) covers important new trials in cardiology therapies and prevention of cardiovascular problems. The world authorities on pharmacologic clinical trials write about the trials, the outcomes and importance for clinical practice.

This book gives the general cardiologist insight into the development of new therapies in cardiology as well as the process of how trials were used for those therapies. In addition to providing a manual for how to establish trials, trials for treatment and prevention are covered.

This book offers indispensable guidance for clinical decision-making in all patient care settings!

• Evidence-based research to guide clinical practice.
• Coverage of treatment trials including Glycoprotein IIb/IIa receptor inhibitors, aspirin, drug therapies for arrhythmias, and pacing.
• Expanded section on prevention of cardiac disease
• Covers both prevention and treatment.

Data and Safety Monitoring Boards in Randomized Trials

Coronary Artery Bypass Surgery

Implantable Cardioverter-Defibrillators and Cardiac Resynchronization Therapy

Postmenopausal Hormone Therapy

JoAnn Manson, MD, DrPH, Professor of Medicine, Harvard Medical School; Chief, Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA; Julie E. Buring, ScD, Professor of Ambulatory Care and Prevention, Harvard Medical School; Deputy Director, Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA; Paul M. Ridker, MD, MPH, Associate Professor of Medicine, Harvard Medical School Director of the Center for Cardiovascular Disease Prevention, Director of Cardiovascular Disease Research, Co-Director of Blood Studies, Division of Preventive Medicine, Brigham and Women's Hospital, Harvard School of Medicine, Brigham and Women's Hospital, Boston, MA; and J. Michael Gaziano, MD, MPH, Associate Professor of Medicine, Harvard Medical School, Co-Director of Cardiovascular Disease Research and Co-Director of Blood Studies, Division of Preventive Medicine, Brigham and Women's Hospital, Preventive Medicine Division, Boston, MA