Clinical Trials in Neurology: Design, Conduct, Analysis

Translating laboratory discoveries into successful therapeutics can be difficult. Clinical Trials in Neurology aims to improve the efficiency of clinical trials and the development of interventions in order to enhance the development of new treatments for neurologic diseases. It introduces the reader to the key concepts underpinning trials in the neurosciences. This volume tackles the challenges of developing therapies for neurologic disorders from measurement of agents in the nervous system to the progression of clinical signs and symptoms through illustrating specific study designs and their applications to different therapeutic areas. Clinical Trials in Neurology covers key issues in Phase I, II and III clinical trials, as well as post-marketing safety surveillance. Topics addressed include regulatory and implementation issues, outcome measures and common problems in drug development. Written by a multidisciplinary team, this comprehensive guide is essential reading for neurologists, psychiatrists, neurosurgeons, neuroscientists, statisticians and clinical researchers in the pharmaceutical industry.

Bernard Ravina is Medical Director, Translational Neurology at Biogen Idec in Cambridge, Massachusetts and Adjunct Associate Professor of Neurology at the University of Rochester School of Medicine, New York, USA.

Jeffrey Cummings is Director of the Cleveland Clinic Lou Ruvo Center for Brain Health in Nevada, Ohio and Florida, USA.

Michael McDermott is Professor of Biostatistics and Professor of Neurology at the University of Rochester School of Medicine, New York, USA.

Michael Poole is Chief Medical Officer of Link Medicine, Cambridge, Massachusetts, USA.