Cocaine and Methamphetamine Dependence: Advances in Treatment provides a comprehensive summary of what psychiatrists and residents need to know about stimulant dependence and its treatment in order to move beyond the basics of this complex disorder. Ever-clearer evidence suggests stimulant dependence can be considered a brain disease. Indeed, neuroimaging studies indicate stimulant dependence may be acquired through epigenetic activation of a preexisting vulnerability in particular genes opening up opportunities to correct the underlying neurochemical abnormalities at the genetic level. Treatments for stimulant dependence are rapidly evolving, and this volume focuses on empirically validated treatments combining medication with behavior therapy. In addition, the authors report on a recent shift to more humane responses within the criminal justice system that has become crucial in obtaining treatment for the estimated 1.6 million cocaine and half-million methamphetamine users who abuse these drugs each day. Current, focused coverage of these and other key treatment considerations, such as HIV comorbidity and polydrug abuse, make this book essential reading for mental health clinicians.

About the Author

Thomas R. Kosten, M.D., is J.H. Waggoner Chair and Professor of Psychiatry, Pharmacology and Neuroscience and Associate Vice President and Dean for Clinical Research at the Baylor College of Medicine, Houston, Texas. He is also Professor of Psychiatry and Epidemiology at the M.D. Anderson Cancer Center, and Director, VA National Substance Use Disorders, Quality Enhancement Research Initiative (QUERI). Thomas F. Newton, M.D., is Professor of Psychiatry and Pharmacology at the Baylor College of Medicine and Michael E. DeBakey VA Medical Center, Houston, Texas. Richard De la Garza II, Ph.D., is Associate Professor of Psychiatry, Neuroscience, and Pharmacology at the Baylor College of Medicine and Michael E. DeBakey VA Medical Center, Houston, Texas. He is also Research Director and Associate Professor, Departments of Psychiatric Oncology and Behavioral Science, at the University of Texas M.D. Anderson Cancer Center. Colin N. Haile, M.D., Ph.D., is Assistant Professor of Psychiatry and Behavioral Sciences at the Baylor College of Medicine and Michael E. DeBakey VA Medical Center, Houston, Texas.

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