Colon-Targeted Therapies Using Co-Amorphous Systems: Innovations in Pelletized Drug Delivery for GI-Sensitive and Poorly Soluble Drugs

Bhagwat, Ajay Ashok; Gandhi, Bipin Raychand; Doke, Rohit Ramesh

ISBN 10: 9999328881 / ISBN 13: 9789999328883

Published by Eliva Press, 2025

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Bibliographic Details

• Title: Colon-Targeted Therapies Using Co-Amorphous Systems: Innovations in Pelletized Drug Delivery for GI-Sensitive and Poorly Soluble Drugs
• Publisher: Eliva Press
• Publication Date: 2025
• Language: English
• ISBN 10: 9999328881
• ISBN 13: 9789999328883
• Binding: Soft cover
• Condition: New

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Synopsis

The colon has emerged as a critical target site for the delivery of therapeutic agents, not only for the local treatment of diseases such as ulcerative colitis, Crohn’s disease, and colorectal cancer but also for the systemic delivery of peptides, proteins, and other drugs that degrade in the upper gastrointestinal (GI) tract. As challenges persist in achieving site-specific delivery and ensuring drug stability and bioavailability in the dynamic environment of the GI tract, the development of novel formulation strategies is of paramount importance. Co-Amorphous Pellets for Colon Targeted Delivery presents a timely and comprehensive exploration of a promising formulation approach at the intersection of material science, pharmaceutics, and drug delivery technology. This book delves deeply into the innovative use of co-amorphous drug systems, a relatively new but rapidly advancing field formulated into pelletised dosage forms designed specifically for colon-targeted delivery. Co-amorphous systems, in which an active pharmaceutical ingredient (API) is stabilised in its amorphous form via molecular interactions with a small molecule co-former, offer a powerful alternative to traditional solid dispersions or crystalline drug forms. By preventing recrystallisation and improving drug solubility and dissolution rates, co-amorphous systems can dramatically enhance the therapeutic performance of poorly water-soluble drugs. In a time when personalised and targeted drug delivery is gaining increasing importance, this book contributes to a deeper understanding of co-amorphous systems and their vast potential in addressing solubility and targeting challenges. It provides a strong foundation and practical guidance for developing next-generation colon-targeted therapies using co-amorphous pellet formulations.