This book constitutes the refereed proceedings of the 4th RECOMB Comparative Genomics Satellite Workshop, RECOMB-CG 2006. The 17 revised full papers presented were carefully reviewed and selected from 34 initial submissions. The papers address a broad variety of aspects and components of the field of comparative genomics, ranging from new quantitative discoveries about genome structure and process to theorems on the complexity of computational problems inspired by genome comparison.

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"Comparative genomics is an exciting new field of bioinformatics dealing with problems of vital importance for many areas in biology. ... This volume contains the 17 fully refereed papers presented at the fourth meeting, held in Montreal in September 2006. ... I consider this book essential for libraries aiming to support research in any field of bioinformatics." (N. Sapidis, ACM Computing Reviews, Vol. 49 (4), April, 2008)

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