Complement and Kidney Disease

Peter F Zipfel

ISBN 10: 3764371668 / ISBN 13: 9783764371661

Published by Springer, Basel, Birkhäuser Basel, Birkhäuser Dez 2005, 2005

About this Item

This item is printed on demand - it takes 3-4 days longer - Neuware -It is evident that a defective or deregulated complement system results in kidney diseases. An important role of complement effector and regulatory proteins in pathological settings of the kidney has been demonstrated. A large panel of distinct human kidney diseases is caused by defective complement control. Genetic analyses have identified mutations in complement regulators that are associated with these diseases. Mutations have been identified in the fluid phase alternative pathway regulator Factor H and the membrane regulator Membrane Cofactor Protein MCP (CD46). The functional characterization of the mutant proteins allows to define the pathophysiological events on a molecular level. These new concepts and data on disease mechanisms allowed establishing new diagnostic and promising therapeutic approaches for several human kidney diseases. Molecular biology, clinics and therapy are discussed in this volume. 236 pp. Englisch.

Seller Inventory # 9783764371661

Bibliographic Details

• Title: Complement and Kidney Disease
• Publisher: Springer, Basel, Birkhäuser Basel, Birkhäuser Dez 2005
• Publication Date: 2005
• Language: English
• ISBN 10: 3764371668
• ISBN 13: 9783764371661
• Binding: Buch
• Condition: Neu
• Dimensions: 235W x 188H x 35D millimeters 235 millimeters width by 188 millimeters height by 35 millimeters depth
• Weight: 714 grams

About this title

Synopsis

It is evident that a defective or deregulated complement system results in kidney diseases. An important role of complement effector and regulatory proteins in pathological settings of the kidney has been demonstrated. A large panel of distinct human kidney diseases is caused by defective complement control. Genetic analyses have identified mutations in complement regulators that are associated with these diseases. Mutations have been identified in the fluid phase alternative pathway regulator Factor H and the membrane regulator Membrane Cofactor Protein MCP (CD46). The functional characterization of the mutant proteins allows to define the pathophysiological events on a molecular level. These new concepts and data on disease mechanisms allowed establishing new diagnostic and promising therapeutic approaches for several human kidney diseases. Molecular biology, clinics and therapy are discussed in this volume.