Complement and Kidney Disease

Peter F Zipfel

ISBN 10: 3764371668 / ISBN 13: 9783764371661

Published by Birkhäuser, Birkhäuser Dez 2005, 2005

About this Item

This item is printed on demand - Print on Demand Titel. Neuware -It is evident that a defective or deregulated complement system results in kidney diseases. An important role of complement effector and regulatory proteins in pathological settings of the kidney has been demonstrated. A large panel of distinct human kidney diseases is caused by defective complement control. Genetic analyses have identified mutations in complement regulators that are associated with these diseases. Mutations have been identified in the fluid phase alternative pathway regulator Factor H and the membrane regulator Membrane Cofactor Protein MCP (CD46). The functional characterization of the mutant proteins allows to define the pathophysiological events on a molecular level. These new concepts and data on disease mechanisms allowed establishing new diagnostic and promising therapeutic approaches for several human kidney diseases. Molecular biology, clinics and therapy are discussed in this volume.Springer Nature c/o IBS, Benzstrasse 21, 48619 Heek 260 pp. Englisch.

Seller Inventory # 9783764371661

Bibliographic Details

• Title: Complement and Kidney Disease
• Publisher: Birkhäuser, Birkhäuser Dez 2005
• Publication Date: 2005
• Language: English
• ISBN 10: 3764371668
• ISBN 13: 9783764371661
• Binding: Buch
• Condition: Neu
• Dimensions: 241W x 160H x 21D millimeters 241 millimeters width by 160 millimeters height by 21 millimeters depth
• Weight: 606 grams

About this title

Synopsis

It is evident that a defective or deregulated complement system results in kidney diseases. An important role of complement effector and regulatory proteins in pathological settings of the kidney has been demonstrated. A large panel of distinct human kidney diseases is caused by defective complement control. Genetic analyses have identified mutations in complement regulators that are associated with these diseases. Mutations have been identified in the fluid phase alternative pathway regulator Factor H and the membrane regulator Membrane Cofactor Protein MCP (CD46). The functional characterization of the mutant proteins allows to define the pathophysiological events on a molecular level. These new concepts and data on disease mechanisms allowed establishing new diagnostic and promising therapeutic approaches for several human kidney diseases. Molecular biology, clinics and therapy are discussed in this volume.