Complement and Kidney Disease

Peter F Zipfel

ISBN 10: 3764371668 / ISBN 13: 9783764371661

Published by Birkhäuser, 2005

About this Item

Complement and Kidney Disease | Peter F Zipfel | Buch | Progress in Inflammation Research | xvi | Englisch | 2005 | Birkhäuser | EAN 9783764371661 | Verantwortliche Person für die EU: Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu Print on Demand.

Seller Inventory # 102226918

Bibliographic Details

• Title: Complement and Kidney Disease
• Publisher: Birkhäuser
• Publication Date: 2005
• Language: English
• ISBN 10: 3764371668
• ISBN 13: 9783764371661
• Binding: Buch
• Condition: Neu
• Dimensions: 241W x 160H x 21D millimeters 241 millimeters width by 160 millimeters height by 21 millimeters depth
• Weight: 606 grams
• Seller catalogs:
  • Bücher

About this title

Synopsis

It is evident that a defective or deregulated complement system results in kidney diseases. An important role of complement effector and regulatory proteins in pathological settings of the kidney has been demonstrated. A large panel of distinct human kidney diseases is caused by defective complement control. Genetic analyses have identified mutations in complement regulators that are associated with these diseases. Mutations have been identified in the fluid phase alternative pathway regulator Factor H and the membrane regulator Membrane Cofactor Protein MCP (CD46). The functional characterization of the mutant proteins allows to define the pathophysiological events on a molecular level. These new concepts and data on disease mechanisms allowed establishing new diagnostic and promising therapeutic approaches for several human kidney diseases. Molecular biology, clinics and therapy are discussed in this volume.