Complement and Kidney Disease (Progress in Inflammation Research)
Language: English
Published by Birkhäuser, 2005
- Hardcover
- New

Seller: Ria Christie Collections, Uxbridge, United KingdomRia Christie Collections
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- Title
- Complement and Kidney Disease (Progress in Inflammation Research)
- Publisher
- Birkhäuser
- Publication year
- 2005
- Condition
- New
- Binding
- Hardcover
- Language
- English
- ISBN 10
- 3764371668
- ISBN 13
- 9783764371661
It is evident that a defective or deregulated complement system results in kidney diseases. An important role of complement effector and regulatory proteins in pathological settings of the kidney has been demonstrated. A large panel of distinct human kidney diseases is caused by defective complement control. Genetic analyses have identified mutations in complement regulators that are associated with these diseases. Mutations have been identified in the fluid phase alternative pathway regulator Factor H and the membrane regulator Membrane Cofactor Protein MCP (CD46). The functional characterization of the mutant proteins allows to define the pathophysiological events on a molecular level. These new concepts and data on disease mechanisms allowed establishing new diagnostic and promising therapeutic approaches for several human kidney diseases. Molecular biology, clinics and therapy are discussed in this volume.
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Ria Christie Collections
Uxbridge, United Kingdom
AbeBooks seller since March 25, 2015
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