Computational Methods for Fragment Spectrum Interpretation : Computational Interpretation of Tandem MS Spectra Including Fragment Ions with Post-Translational Modifications

Language: English

Published by VDM Verlag Dr. Müller, 2010

3639228588 / 9783639228588

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Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH

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nach der Bestellung gedruckt Neuware - Printed after ordering - Post-translational modifications (PTMs) are of critical importance for a vast range of cellular processes such as growth control and signal transduction. Mass spectrometry (MS) can shed light on the characteristics of PTMs to gain insight into the mechanisms of numerous diseases including cancer. However, interpretation of tandem MS spectra including fragment ions with PTMs from high-throughput experiments is a complex challenge. The high number and diversity of known PTMs as well as suboptimal quality of spectra compromise the identification of PTMs in MS experiments. In this book, an efficient algorithm for the computational interpretation of tandem MS spectra including fragment ions with PTMs is described. Information on both precursor and fragment ion level is utilized and an arbitrary number of PTMs is considered. A robust statistical noise intensity model is developed to compensate for low spectrum quality. Finally, the algorithm is successfully applied on the fragment spectra in the PRIDE proteomics data repository to render it suitable for statistical machine learning investigations. …

Seller Inventory # 9783639228588

Title
Computational Methods for Fragment Spectrum Interpretation : Computational Interpretation of Tandem MS Spectra Including Fragment Ions with Post-Translational Modifications
Author
Jonathan Rameseder
Publisher
VDM Verlag Dr. Müller
Publication year
2010
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3639228588
ISBN 13
9783639228588
Item weight
100 grams
Dimensions
22.00x15.00x0.30 cm

AHA-BUCH GmbH

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