Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models

Language: English

Published by Springer, 2018

3319807080 / 9783319807089

Series: Book 83 of 111 - Lecture Notes in Computational Science and Engineering

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Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH

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Druck auf Anfrage Neuware - Printed after ordering - Flow of ions through voltage gatedchannels can be represented theoretically using stochastic differentialequations where the gating mechanism is represented by a Markov model. The flow through achannel can be manipulated using various drugs, and the effect of a given drugcan be reflected bychanging the Markov model. These lecture notes provide an accessibleintroduction to the mathematical methods needed to deal with these models. They emphasize the use ofnumerical methods and provide sufficient details for the reader to implementthe models and thereby study the effect of various drugs. Examples in thetext include stochastic calcium release from internal storage systems in cells,as well as stochasticmodels of the transmembrane potential. Well known Markov models are studied anda systematic approach toincluding the effect of mutations is presented. Lastly, the book shows how to derive the optimal propertiesof a theoretical model of a drug for a given mutation defined in termsof a Markov model.

Seller Inventory # 9783319807089

Title
Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models
Author
Glenn T. Lines
Publisher
Springer
Publication year
2018
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3319807080
ISBN 13
9783319807089
Item weight
441 grams
Dimensions
235x155x16 mm
Series
Book 83 of 111: Lecture Notes in Computational Science and Engineering

AHA-BUCH GmbH

Einbeck, Germany

5-star seller

AbeBooks seller since August 14, 2006

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