Title: Conception, d�veloppement et caract�risation in vitro de comprim�s de dof�tilide: bas�s sur un syst�me d'administration pulsatile de m�dicaments (French Edition)
Publisher: Editions Notre Savoir
Publication Date: 2024
Language: French
ISBN 10: 6208035678
ISBN 13: 9786208035679
Binding: Soft cover
Condition: New

About this title

Synopsis

L'objectif de ce livre est de d�velopper et de caract�riser un syst�me d'administration pulsatile d'un nouveau m�dicament, le dof�tilide. Initialement, les comprim�s de base ont �t� pr�par�s en utilisant diff�rentes concentrations de super d�sint�grants, les comprim�s de base formul�s ont �t� enrob�s avec les polym�res en utilisant la technologie d'enrobage par compression. Le glycollate d'amidon sodique, la povidone crois�e et la carmellose sodique crois�e �taient les super d�sint�grants utilis�s dans la formulation des comprim�s de base. Toutes les formulations de comprim�s enrob�s par pressage ont �t� soumises � divers tests d'�valuation physique et chimique pour les comprim�s enrob�s par pressage et les comprim�s enrob�s par pressage. L'�paisseur, la duret� et la variation de poids de toutes les formulations de comprim�s se sont r�v�l�es conformes aux limites officielles de la pharmacop�e. L'enrobage par compression a �t� r�alis� en utilisant Eudragit S 100, Eudragit L 100 et l'�thylcellulose comme polym�res d'enrobage. Les donn�es relatives � la lib�ration maximale du m�dicament ont �t� obtenues en utilisant une combinaison de polym�res dans un rapport de 1:1. Ce livre sera certainement utile aux chercheurs qui souhaitent concevoir et fabriquer des syst�mes d'administration de m�dicaments pulsatiles pour de meilleurs r�sultats th�rapeutiques.

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