Conditional Mutagenesis: An Approach to Disease Models (Handbook of Experimental Pharmacology (178))

Leading experts provide timely and comprehensive information on methods for conditional mutagenesis in the mouse (part 1) and their application to model human physiology and pathophysiology (part 2). It illustrates how sophisticated genetic manipulations of the mouse genome are employed to model human diseases and to identify underlying molecular mechanisms. Finally the book considers the development of new drugs to treat them.

From the reviews:

"This is a comprehensive overview of generating mouse models with conditional modification of genes to study the effects of gene dysfunction in the development of human diseases. ... The authors target general scientific researchers ... . This book will be very informative for any scientists and students interested in using or generating genetically modified mouse models in biomedical research. ... an excellent reference on the most recent progress in generating conditional knockout mice." (Grace L Guo, Doody’s Review Service, July, 2008)