Connexin Cell Communication Channels: Roles in the Immune System and Immunopathology

Plasma membrane-associated channels known as gap junctions, along with their protein building blocks-connexins-have an important functional role in a range of immunological processes. This book assembles and synthesizes four decades of the most important research carried out in this field. The chapters focus on the latest progress made on translating the knowledge gained to specific treatment modalities, including approaches for reducing scarring and cardiac arrhythmia, combating inflammation in the central nervous system and enhancing epithelial tissue repair. The book will inform and update specialists, clinical practitioners and those studying the potential for commercial applications.

Ernesto Oviedo-Orta received his MD from the Havana Medical School in Cuba where he also specialized in clinical immunology. During his postgraduate specialist training, he engaged in vaccine research related to diverse infectious agents and diseases, including measles and hepatitis C. Dr. Oviedo-Orta’s Ph.D. research work in Cardiff, UK, focused on the role of gap junction intercellular communication in the immune system. His work continued in this area both in Bristol and Guildford, UK, but with special attention to immune regulation. Dr. Oviedo-Orta is currently a Clinical Sciences Expert at Novartis Vaccines & Diagnostics, Siena, Italy, where he is a medical and scientific advisor supporting new and ongoing projects in vaccine research and clinical development.

Brenda R. Kwak studied at the University of Amsterdam, the Netherlands, where she also obtained her PhD. Dr. Kwak carried out her PhD research work focusing on the regulation of cardiac gap junction channels using a dual patch-clamp approach. She then continued her work for several years as a postdoctoral fellow at the University of Utrecht, the Netherlands. After moving to the University of Geneva, she focused on the vascular system, first in the endothelium at the Department of Morphology, and later on the regulation of major histocompatibility complex class II (MHC-II) in the context of atherosclerosis at the Department of Internal Medicine―Cardiology. On receiving a professorship from the Swiss National Science Foundation in 2003, she established an independent research group in the same department to dissect the role of Cxs in atherosclerosis. She is now associate professor to both the Department of Pathology and Immunology and to the Department of Internal Medicine―Cardiology at the University of Geneva and focuses more broadly on the role of Cxs in cardiovascular physiology and pathology, work that still includes atherosclerotic disease but also restenosis, ischemia-reperfusion injury of the heart, platelet activation, thrombosis, and the lymphatic system.

William Howard Evans, PhD, is professor of medical biochemistry in the Institute of Infection and Immunity at Cardiff University Medical School, United Kingdom. His interest in intercellular communication via gap junctions spans from 1972 and his group has studied many facets of the structure and function of these Cx-based channels in a variety of normal and pathological situations. His recent studies focus on addressing the roles of Cx channels in translational medicine. This has involved the design and development of small Cx mimetic peptides that block the operation of these channels. He also studies their use in addressing cardiac pathology.