The value of ultrasound contrast agents (USCA) in clinical practice depends on the pharmacokinetics, the signal processing, and the contrast-specific imaging modalities. USCA are exogenous non-toxic substances smaller than red blood cells,which after intravenous administration must be stable enough to pass through the pulmonary capillary bed and enter the blood pool producing the necessary contrast enhancement for the duration of the examination. Recently, second-generation agents, such as SonoVue (Bracco Imaging SpA,Milan,Italy),have been introduced into the market. These agents,taking advantage of the stability of their microbubbles,withstand the acoustic pressure of insonation much better than previous USCA,resulting in an increased half-life of the agent and thus in a prolonged diagnostic window. These agents are blood pool agents that remain in the intravascular compartment and do not leak into the organ tissue. Therefore,they are used to - crease the Doppler signal amplitude during their dynamic vascular phase. Concomitant with the improvement of contrast agents,d- ferent contrast-specific imaging modalities have been developed which,used in combination with USCA and a low mechanical - dex (MI),allow continuous real-time grey-scale imaging. These - cent technical improvements have opened new possibilities in the use of USCA in a variety of indications,as shown in the contributions contained in this book. In the following chapters,some of the most distinguished users of second-generation USCA will share their knowledge and experience. The first contributor is Dr. Thomas Albrecht,Department of - diology, University Hospital of Berlin, Germany.
The value of ultrasound contrast agents (USCA) in everyday clinical practice depends on the pharmacokinetics, the signal processing, and the contrast-specific imaging modalities.
Second-generation USCA, are blood pool agents that do not leak into the organ tissue to be examined but remain in the intravascular compartment increasing the Doppler signal amplitude during their dynamic vascular phase. Taking advantage of the stability of their microbubbles, they can withstand the acoustic pressure of insonation much better than first-generation contrast media, which results in an increased half-life of the agent and, consequently, in a prolonged diagnostic window.
Concomitant with the improvement of contrast agents, different contrast-specific imaging modalities have been developed which, used in combination with USCA and a low mechanical index, allow continuous real-time grey-scale imaging. These recent technical improvements have opened new possibilities in the use of USCA in a variety of indications. Written by internationally renowned experts, the contributions gathered in this book give an overview of current and possible future new applications of USCA in routine and clinical practice.
