A Contribution to the Study of the Nature and Origin of the Bence Jones Protein
Language: English
Published by Forgotten Books, 2018
- Softcover
- New
Seller: Forgotten Books, London, United KingdomForgotten Books
AbeBooks seller since June 2, 2021
Condition: New
US$ 17.87
Quantity: Over 20 available
Add to basketItem description from seller
Print on Demand. This book is a study of a protein, called Bence Jones protein, which is excreted in the urine of people with certain bone marrow disorders. The author begins by reviewing the history of the discovery of this protein and its association with multiple myeloma, a type of bone cancer. The author then discusses the possible causes of Bence Jones proteinuria, focusing on the theory that it is produced by the action of enzymes released by the abnormal cells in the bone marrow. The author also discusses the various theories about the composition and structure of Bence Jones protein and explores the possibility that it is related to other proteins in the body, such as serum globulin. Finally, the author presents the results of his own experiments, in which he injected products of the enzymatic digestion of bone marrow into dogs and observed the effects on their urine. The author concludes that his results support the theory that Bence Jones protein is produced by the action of enzymes on bone marrow proteins and that it is excreted in the urine as a waste product of this process. This book provides a comprehensive overview of the current state of knowledge about Bence Jones protein and its role in multiple myeloma. It is a valuable resource for researchers and clinicians interested in this topic. This book is a reproduction of an important historical work, digitally reconstructed using state-of-the-art technology to preserve the original format. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in the book.…
Seller Inventory # 9781334330223_0
- Title
- A Contribution to the Study of the Nature and Origin of the Bence Jones Protein
- Author
- Jacob Rosenbloom
- Publisher
- Forgotten Books
- Publication year
- 2018
- Condition
- New
- Book Type
- print-on-demand item
- Binding
- Paperback
- Language
- English
- ISBN 10
- 1334330220
- ISBN 13
- 9781334330223
- Seller catalogs
- Chemistry
This study is a continuation of the preliminary work by Ottenberg and Gies who found in this laboratory that crude elastose, after its subcutaneous or intraperitoneal injection, can readily be detected in the urine by the heat precipitation test. Since the Bence Jones protein has various properties in common with elastoses, Ottenberg and Gies suggested that osseoalbumoid (bone elastin might be the forerunner of the Bence Jones protein, which appears in the urine of people with multiple myeloma of the bones. It was thought that perhaps the osseoalbumoid of the bone might be so acted upon by the enzymes present in the cells of the myelomatous growth, as to give rise to a body having the properties of the Bence Jones protein.
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Forgotten Books
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Forgotten Books’ Classic Reprint Series utilizes the latest technology to regenerate facsimiles of historically important writings. Careful attention has been made to accurately preserve the original format of each page whilst digitally enhancing the quality of the aged text.
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