Copolypeptide Vesicles: Size Control for Intracellular Drug Delivery : Self-Assembled Copolypeptide Morphologies for Biomedical Applications

Language: English

Published by VDM Verlag Dr. Müller, 2009

363917996X / 9783639179965

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Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH

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nach der Bestellung gedruckt Neuware - Printed after ordering - Much focus has been given to the synthesis of polypeptidic based materials due to their unique structural features. These polypeptides commonly are amphiphilic in character that benefit from secondary structural features associated with one of the polymer blocks. These features, such as alpha- helix and beta-sheet conformations, allow for control over nanoscale ordering through self- assembly for use in biological sensors and therapeutic drug delivery. We report the preparation and characterization of charged amphiphilic block copolypeptide vesicle formers using transition metal mediated living ring-opening polymerization of N- carboxyanhydrides (NCAs). The vesicle membranes show fluidic properties suggested by dynamic physical behavior allowing for fine size adjustments using liposomal extrusion methods. This extrusion also allows for a facile mode of encapsulation of biomolecules for drug delivery. Modification of the charged residues has shown vesicle stability under osmotic and thermal stress, in pH buffers, and serum cell media, as well as the ability for lipid and cellular interactions.…

Seller Inventory # 9783639179965

Title
Copolypeptide Vesicles: Size Control for Intracellular Drug Delivery : Self-Assembled Copolypeptide Morphologies for Biomedical Applications
Author
Eric Holowka
Publisher
VDM Verlag Dr. Müller
Publication year
2009
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
363917996X
ISBN 13
9783639179965
Item weight
403 grams
Dimensions
220x176x33 mm

AHA-BUCH GmbH

Einbeck, Germany

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AbeBooks seller since August 14, 2006

Shipping rates from Germany to U.S.A.

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