Since several excellent books have appeared on the issue of chemical and biochemical sensing, this compendium concentrates on recent creative new approaches using chemical means for the detection and quanti?cation of - portant analytes. These are presented either from a technical viewpoint or fromtheperspectiveofselectivemolecularrecognitionwitharti?cialreceptor molecules. Consequently, the entire book is subdivided into two categories, i. e., natural targetsand detection techniques. In the ?rst part, the challenging task of sensing peptides and proteins as wellassaccharidesisaddressedfromseveralperspectives: Smalllibrarieswith maximum diversity are ef?ciently used to reach high af?nity and selectivity of arti?cial hosts for short peptide sequences. Preorganized aromatic vessels are tailored for certain protein epitopes and shown to selectively address the prion protein, and a new conjugation technique operating at physiological conditions on helix-loop-helix motifs, leads to protein binders of exquisite af?nity. Finally, elegant sensor systems for multifunctional carbohydrates in their naturalform, whichuse theprinciple ofphoto-induced electrontransfer for ?uorescence detection, are presented. The second part of this book is devoted to creative detection techniques employing chemical processes: Liposomes with integral self-assembled - acetylene lipid areas show an intense blue color, which gradually changes to red if biological analytes of various sizes speci?cally interact with emb- ded hosts. Principal component analysis and arti?cial neuronal networks are novel methods to quantitatively analyze complex mixtures. An alternative - proach uses arti?cial peptidic pores, which are able to release self-quenched ?uorophoresthataresubstitutedbytighterbindinganalytes.
From the reviews:
"Schrader has compiled an excellent set of articles that present a current snapshot of chemical sensing utilizing state-of-the-art approaches ranging from combinatorial receptor libraries to artificial membrane pores. ... This volume is an excellent read for the budding and seasoned bioorganic chemist, chemical biologist, or supramolecular chemist as well as for those in allied fields who wish to apply emerging chemical techniques to solve current problems in chemical sensing. I highly recommend addition of this text to the collections of science libraries." (Indraneel Ghosh, Journal of the American Chemical Society, Vol. 130 (13), 2008)
"This book provides an overview of recent creative new approaches which use chemical means of detection and quantification of important analytes. ... Creative chemical sensor systems is a rapidly growing subject. ... It is a very useful guide to laboratory practice, especially for searching for literature references. The book reads well and contains valuable information for scientists ... . is well-structured, and the chapters can be read independently of each other." (Karin Wöllner, Analytical and Bioanalytical Chemistry, June, 2008)
