Cryo-EM Part A: Sample Preparation and Data Collection is dedicated to a description of the instruments, samples, protocols, and analyses that belong to cryo-EM. It emphasizes the relatedness of the ideas, instrumentation, and methods underlying all cryo-EM approaches, which allow practitioners to easily move between them. Within each section, the articles are ordered according to the most common symmetry of the sample to which their methods are applied.

Includes time-tested core methods and new innovations applicable to any researcher
Methods included are useful to both established researchers and newcomers to the field
Relevant background and reference information given for procedures can be used as a guide

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