Crystallization of Nucleic Acids and Proteins: A Practical Approach

Arnaud Ducruix et Richard Giege

ISBN 10: 0199632456 / ISBN 13: 9780199632459

Published by Oxford University Press, 1992

About this Item

Ancien livre de bibliothèque. Légères traces d'usure sur la couverture. Edition 1992. Ammareal reverse jusqu'à 15% du prix net de cet article à des organisations caritatives. ENGLISH DESCRIPTION Book Condition: Used, Very good. Former library book. Slight signs of wear on the cover. Edition 1992. Ammareal gives back up to 15% of this item's net price to charity organizations.

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Bibliographic Details

• Title: Crystallization of Nucleic Acids and Proteins: A Practical Approach
• Publisher: Oxford University Press
• Publication Date: 1992
• Language: English
• ISBN 10: 0199632456
• ISBN 13: 9780199632459
• Binding: Hardcover
• Condition: Très bon

About this title

Synopsis

In the last decade crystallography has emerged as a key tool for understanding the structures of biological macromolecules, yet the crystallization techniques themselves have been perceived as difficult to perform. This book provides a detailed guide to producing crystals of proteins and nucleic acids for diffraction studies. Standard crystallization methods are given, along with procedures for the preparation and handling of macromolecules. Other topics covered include seeding procedures, crystallization in gels, under microgravity and supergravity, crystallization of nucleic acids, nucleic acid-protein complexes and membrane proteins, an introduction to X-ray crystallography and automated processes. Detailed laboratory protocols and the underlying theoretical background are brought together, providing researchers with the conceptual and methodological tools necessary to exploit these techniques.

Review

'a work that is both a laboratory manual and a treatise on the physics of crystallization ... this is a modern laboratory manual useful for anyone working in this research area ... Its value to the experimentalist lies in the presentation of techniques and, probably more importantly, in the discussions of crystallization theory.' Patricia C. Weber, The Du Pont Merck Pharmaceutical Co. Acta Cryst. (1994) 'an invaluable contribution to the literature in this research area ... it will be most useful for students and beginners in the field of crystallization ... this very up-to-date, comprehensive text ... is written and presented with great clarity. I can strongly recommend it as a standard text on crystallization that no laboratory involved in the field should be without.' Lesley F. Lloyd, Imperial College of Science, Technology and Medicine, Tibtech, April 1993 (Vol. 11)