Current Concepts in Autoimmunity and Chronic Inflammation

Language: English

Published by Springer, 2006

3540297138 / 9783540297130

Series: Book 20 of 322 - Current Topics in Microbiology and Immunology

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Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH

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Druck auf Anfrage Neuware - Printed after ordering - The immune system has been known to be capable of distinguishing self from non-self since the pioneering work of Paul Erhlich more than a century ago. Originally described in experiments studying blood transfusion comp- ibility, the principle of 'horror autotoxicus' is still valid, although today the phenomenon is usually described in terms of tolerance or ignorance. A great deal has been learned about the various processes preventing self-reactivity normally. These include processes that operate during immune cell ontogeny and subsequently on reactivity of mature lymphocytes in the periphery. They encompass mechanisms that are intrinsic to potentially reactive lymphocytes and can result in central or peripheral deletion or the alteration of functional potential. In addition, there are in uences that are extrinsic to potentially auto-reactive lymphocytes, including the function of regulatory cells, d- ferentiation state of antigen-presenting cells, availability of self-antigen, the cytokine and chemokine milieu, as well as the traf cking patterns involved in generating productive immune interactions. It is clear that the immune system devotes a considerable effort to the avoidance of the development of potentially pathogenic self-reactivity. Despite this, the development of self-reactivity is relatively common. - though the development of autoimmune disease is less frequent, autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, systemic lupus e- thematosus, psoriasis, thyroiditis, and myasthenia gravis, are all too common, and can cause considerable morbidity and even mortality.

Seller Inventory # 9783540297130

Title
Current Concepts in Autoimmunity and Chronic Inflammation
Author
Peter E. Lipsky
Publisher
Springer
Publication year
2006
Condition
Neu
Binding
Buch
Language
English
ISBN 10
3540297138
ISBN 13
9783540297130
Item weight
612 grams
Dimensions
241x160x21 mm
Series
Book 20 of 322: Current Topics in Microbiology and Immunology

AHA-BUCH GmbH

Einbeck, Germany

5-star seller

AbeBooks seller since August 14, 2006

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