Current Trends in Antibiotic Resistance in Infectious Diseases

Contents Preface 1 Quorum Sensing and Multiple Antibiotic Resistance 2 Genes Encoding Production of Metallo Lactamases in Most Important Gram Negative Pathogens 3 Ciprofloxacin Resistance Among Uropathogens 4 Metallo Lactamase Producing Klebsiella Pneumoniae 5 Drug Resistance in Marine Bacteria 6 An Overview of the Carbapenems with a Focus on Doripenem The Latest Member of The Carbapenem Class 7 Increasing Importance of Newer Beta Lactamases in Indian 8 Vancomycin Resistant Staphylococcus Aureus A Global Threat 9 Molecular Epidemiology of Ampc Beta Lactamases 10 Cholera and the Acquisition of Antimicrobial Resistance Index This book contains ten chapters which cover current trends on antibiotic resistance in different parts of the world Some of the chapters are dedicated to specific type of bacteria like marine and cholera associated microorganisms Whereas rest of the chapters are mainly focused on the mechanism of drug resistance with special reference to beta lactamases Since most of the antibiotics used to treat infections belong to lactam group which is lactam ring lactam or penam is a lactam with a heteroatomic ring structure consisting of three carbon atoms and one nitrogen atom A lactam is a cyclic amide The main focus of this book is to understand the different molecular markers responsible for developing resistance against this group of antibiotics CTX M family of enzyme which hydrolyzes third generation of cephalosporins preferably cefotaxime belongs to the category of Extended spectrum lactamases ESBLs These types of enzymes are emerging among Gram negative bacteria; predominantly Klebsiella pneumoniae Escherichia coli and other species in different parts of the world In the current scenario the CTX M family includes almost 40 variants The blaTEM and blaSHV are another important class of lactamases most prevalent among enterobacteriacae which are also discussed in this book 272 pp.…