Cytokine Storm Syndrome

Randy Q. Cron

ISBN 10: 3031598148 / ISBN 13: 9783031598142

Published by Springer, Springer Aug 2024, 2024

About this Item

This item is printed on demand - Print on Demand Titel. Neuware -Cytokine Storm Syndromes, including HLH and MAS, are frequently fatal disorders, particularly if not recognized early and treated during presentation. The genetics of Cytokine Storm Syndromes are being defined with many of the risk alleles giving rise to mutations in the perforin-mediated cytolytic pathway used by CD8 cytotoxic T cells and natural killer cells. These are being studied using murine models. Up to 10% of the general population may carry risk alleles for developing Cytokine Storm Syndromes, and Cytokine Storm Syndromes are being increasingly recognized around the world in pediatric and adult hospitals.A variety of infectious, rheumatic, and oncologic triggers are commonly associated with Cytokine Storm Syndromes, but understanding this disorder is critical for all researchers and physicians to ensure timely and appropriate therapy. This second edition addresses all aspects of the disorder, from genetics, pathophysiology, and ongoing research, to clinical presentations, risk factors and treatment. New-to-this-edition features include dedicated chapters on severe COVID-19 CSS, and post-COVID CSS of multi-system inflammatory syndrome in children (MIS-C). In addition, novel topics including CSS associated with Castleman disease, pregnancy, therapeutics, transplantation, and cardiac bypass, as well as treatment with JAK inhibitors are addressed.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 644 pp. Englisch.

Seller Inventory # 9783031598142

Bibliographic Details

• Title: Cytokine Storm Syndrome
• Publisher: Springer, Springer Aug 2024
• Publication Date: 2024
• Language: English
• ISBN 10: 3031598148
• ISBN 13: 9783031598142
• Binding: Buch
• Edition: 2nd Edition
• Condition: Neu
• Dimensions: 260W x 183H x 40D millimeters 260 millimeters width by 183 millimeters height by 40 millimeters depth
• Weight: 1390 grams

About this title

Synopsis

Cytokine Storm Syndromes, including HLH and MAS, are frequently fatal disorders, particularly if not recognized early and treated during presentation. The genetics of Cytokine Storm Syndromes are being defined with many of the risk alleles giving rise to mutations in the perforin-mediated cytolytic pathway used by CD8 cytotoxic T cells and natural killer cells. These are being studied using murine models. Up to 10% of the general population may carry risk alleles for developing Cytokine Storm Syndromes, and Cytokine Storm Syndromes are being increasingly recognized around the world in pediatric and adult hospitals.

A variety of infectious, rheumatic, and oncologic triggers are commonly associated with Cytokine Storm Syndromes, but understanding this disorder is critical for all researchers and physicians to ensure timely and appropriate therapy. This second edition addresses all aspects of the disorder, from genetics, pathophysiology, and ongoing research, to clinical presentations, risk factors and treatment. New-to-this-edition features include dedicated chapters on severe COVID-19 CSS, and post-COVID CSS of multi-system inflammatory syndrome in children (MIS-C). In addition, novel topics including CSS associated with Castleman disease, pregnancy, therapeutics, transplantation, and cardiac bypass, as well as treatment with JAK inhibitors are addressed. 

About the Author

Randy Q. Cron, MD, PhD,

University of Alabama at Birmingham

Professor of Pediatrics and Medicine

Birmingham, Alabama

USA

Edward M. Behrens, MD                 

University of Pennsylvania Perelman School of Medicine

Perelman School of Medicine

Philadelphia, Pennsylvania

USA