Cytokine Storm Syndrome

Randy Q. Cron

ISBN 10: 3031598172 / ISBN 13: 9783031598173

Published by Springer, Springer, 2025

About this Item

Druck auf Anfrage Neuware - Printed after ordering - Cytokine Storm Syndromes, including HLH and MAS, are frequently fatal disorders, particularly if not recognized early and treated during presentation. The genetics of Cytokine Storm Syndromes are being defined with many of the risk alleles giving rise to mutations in the perforin-mediated cytolytic pathway used by CD8 cytotoxic T cells and natural killer cells. These are being studied using murine models. Up to 10% of the general population may carry risk alleles for developing Cytokine Storm Syndromes, and Cytokine Storm Syndromes are being increasingly recognized around the world in pediatric and adult hospitals.A variety of infectious, rheumatic, and oncologic triggers are commonly associated with Cytokine Storm Syndromes, but understanding this disorder is critical for all researchers and physicians to ensure timely and appropriate therapy. This second edition addresses all aspects of the disorder, from genetics, pathophysiology, and ongoing research, to clinical presentations, risk factors and treatment. New-to-this-edition features include dedicated chapters on severe COVID-19 CSS, and post-COVID CSS of multi-system inflammatory syndrome in children (MIS-C). In addition, novel topics including CSS associated with Castleman disease, pregnancy, therapeutics, transplantation, and cardiac bypass, as well as treatment with JAK inhibitors are addressed.

Seller Inventory # 9783031598173

Bibliographic Details

• Title: Cytokine Storm Syndrome
• Publisher: Springer, Springer
• Publication Date: 2025
• Language: English
• ISBN 10: 3031598172
• ISBN 13: 9783031598173
• Binding: Taschenbuch
• Edition: 2nd Edition
• Condition: Neu
• Dimensions: 254W x 178H x 35D millimeters 254 millimeters width by 178 millimeters height by 35 millimeters depth
• Weight: 1192 grams

About this title

Synopsis

Cytokine Storm Syndromes, including HLH and MAS, are frequently fatal disorders, particularly if not recognized early and treated during presentation. The genetics of Cytokine Storm Syndromes are being defined with many of the risk alleles giving rise to mutations in the perforin-mediated cytolytic pathway used by CD8 cytotoxic T cells and natural killer cells. These are being studied using murine models. Up to 10% of the general population may carry risk alleles for developing Cytokine Storm Syndromes, and Cytokine Storm Syndromes are being increasingly recognized around the world in pediatric and adult hospitals.

A variety of infectious, rheumatic, and oncologic triggers are commonly associated with Cytokine Storm Syndromes, but understanding this disorder is critical for all researchers and physicians to ensure timely and appropriate therapy. This second edition addresses all aspects of the disorder, from genetics, pathophysiology, and ongoing research, to clinical presentations, risk factors and treatment. New-to-this-edition features include dedicated chapters on severe COVID-19 CSS, and post-COVID CSS of multi-system inflammatory syndrome in children (MIS-C). In addition, novel topics including CSS associated with Castleman disease, pregnancy, therapeutics, transplantation, and cardiac bypass, as well as treatment with JAK inhibitors are addressed. 

About the Author

Randy Q. Cron, MD, PhD,

University of Alabama at Birmingham

Professor of Pediatrics and Medicine

Birmingham, Alabama

USA

Edward M. Behrens, MD                 

University of Pennsylvania Perelman School of Medicine

Perelman School of Medicine

Philadelphia, Pennsylvania

USA