DEVELOPMENT OF LORNXICAM MICROSPONGES GEL FOR TOPICAL APPLICATION | LORNXICAM MICROSPONGES GEL

Anilkumar Shinde (u. a.)

ISBN 10: 6202519193 / ISBN 13: 9786202519199

Published by LAP LAMBERT Academic Publishing, 2020

DEVELOPMENT OF LORNXICAM MICROSPONGES GEL FOR TOPICAL APPLICATION | LORNXICAM MICROSPONGES GEL | Anilkumar Shinde (u. a.) | Taschenbuch | 108 S. | Englisch | 2020 | LAP LAMBERT Academic Publishing | EAN 9786202519199 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. Seller Inventory # 118403307

Synopsis:

The aim of the present study was to prepare microsponges gel formulation containing lornixicam by quasi emulsion solvent diffusion method. Lornoxicam is a Non-steroidal anti-inflammatory drug used for the treatment of various inflammatory diseases. Microsponges were spherical, uniform in shape, between 19 to 136μm in diameter. The production yield, actual drug content and encapsulation efficiency was found in the range of 57.14±0.47 to 88.57±0.799%, 54.78±0.76 to 83.55±0.65%, and 65.73±0.35 % to 95.04±0.42 respectively. The results of compatibility studies FTIR, PXRD, DSC and accelerated stability studies showed that no chemical interaction with drug and excipients. The dermal observation of skin irritation study shows no sign of either erythema or edema after 24 hrs of application. In % inhibition was more in microsponges gel as compare with pure drug gel in anti- inflammatory activity. Formulation of lornoxicam microsponges provides better control over release of drug. This study presents a new approach based on microsponge drug delivery system for topical application.

Bibliographic Details

Title: DEVELOPMENT OF LORNXICAM MICROSPONGES GEL ...
Publisher: LAP LAMBERT Academic Publishing
Publication Date: 2020
Binding: Taschenbuch
Condition: Neu