DEVELOPMENT AND VALIDATION OF ALLOPURINOL : DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR ESTIMATION OF ALLOPURINOL IN BULK DRUG

P. Sudha Rani

ISBN 10: 6207647017 / ISBN 13: 9786207647019

Published by LAP LAMBERT Academic Publishing

About this Item

nach der Bestellung gedruckt Neuware - Printed after ordering - The study is focused to develop and validate HPLC methods for estimation of Allopurinol in tablet dosage form. For routine analytical purpose it is desirable to establish methods capable of analysing huge number of samples in a short time with good robustness, accuracy and precision without any prior separation steps. HPLC method generates large amount of quality data, which serve as highly powerful and convenient analytical tool. The method shows good reproducibility and good recovery. From the specificity studies, it was found that the developed methods were specific for Allopurinol. The proposed methods were found to be simple, sensitive, accurate and precise and showed no interference from the common additives and excipients. The developed method was validated in terms of linearity, accuracy, precision in accordance with the ICH guidelines. Hence the proposed methods can be routinely used for the estimation of Allopurinol in bulk and pharmaceutical dosage forms.

Seller Inventory # 9786207647019

Bibliographic Details

• Title: DEVELOPMENT AND VALIDATION OF ALLOPURINOL : DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR ESTIMATION OF ALLOPURINOL IN BULK DRUG
• Publisher: LAP LAMBERT Academic Publishing
• Language: English
• ISBN 10: 6207647017
• ISBN 13: 9786207647019
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 4D millimeters 220 millimeters width by 150 millimeters height by 4 millimeters depth
• Weight: 107 grams

About this title

Synopsis

The study is focused to develop and validate HPLC methods for estimation of Allopurinol in tablet dosage form. For routine analytical purpose it is desirable to establish methods capable of analysing huge number of samples in a short time with good robustness, accuracy and precision without any prior separation steps. HPLC method generates large amount of quality data, which serve as highly powerful and convenient analytical tool. The method shows good reproducibility and good recovery. From the specificity studies, it was found that the developed methods were specific for Allopurinol. The proposed methods were found to be simple, sensitive, accurate and precise and showed no interference from the common additives and excipients. The developed method was validated in terms of linearity, accuracy, precision in accordance with the ICH guidelines. Hence the proposed methods can be routinely used for the estimation of Allopurinol in bulk and pharmaceutical dosage forms.